Catalog Number: 1089
Chemical Name: 8-Bromoguanosine cyclic 3',5'-monophosphate sodium salt
Biological Activity
Membrane permeable cGMP analog that activates protein kinase G (PKG). 4.3-fold more potent than cGMP in activating PKG1α and promotes relaxation of tracheal and vascular smooth muscle tissue in vitro.
Technical Data
  • M.Wt:
    446.09
  • Formula:
    C10H10BrN5NaO7P
  • Solubility:
    Soluble to 100 mM in water
  • Purity:
    >98%
  • Storage:
    Desiccate at -20°C
  • CAS No:
    51116-01-9
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis. All Tocris products are intended for laboratory research use only.
Background References
  1. Modulation of agonist-induced calcium mobilisation in bovine aortic endothelial cells by phorbol myristate acetate and cyclic AMP but not cyclic GMP.
    Buchan et al.
    Br.J.Pharmacol., 1991;104:361
  2. Stimulation of phagocytic release of neutral protease from human neutrophils by cholinergic amines and cyclic 3',5'-guanosine monophosphate.
    Ignarro et al.
    J.Immunol., 1974;112:210
  3. Relaxation of pig coronary arteries by new and potent cGMP analogs that selectively activate type 1α, compared with type 1β, cGMP-dependent protein kinase.
    Sekhar et al.
    Mol.Pharmacol., 1992;42:103

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