Biological Activity Nucleoside analog; metabolized in vivo to 8-Chloro-ATP. Incorporates into RNA during transcription and inhibits RNA synthesis. Exhibits cytotoxicity in MM.1S, RPMI-8226 and U266 cancer cell lines; induces G2/M cell cycle arrest and mitotic catastrophe in A549 and H1299 cells.
Soluble to 20 mM in water with gentle warming and to 100 mM in DMSO
Store at -20°C
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For batch specific data refer to the Certificate of Analysis.
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