Nucleoside analog; metabolized in vivo
to 8-Chloro-ATP. Incorporates into RNA during transcription and inhibits RNA synthesis. Exhibits cytotoxicity in MM.1S, RPMI-8226 and U266 cancer cell lines; induces G2
/M cell cycle arrest and mitotic catastrophe in A549 and H1299 cells.
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All Tocris products are intended for laboratory research use only.
8-Chloro-adenosine inhibits growth at least partly by interfering with actin polymerization in cultured human lung cancer cells
Gu et al.
ATP analog enhances the actions of a heat shock protein 90 inhibitor in multiple myeloma cells.
Cervantes-Gomez et al.
Exposure of human lung cancer cells to 8-chloro-adenosine induces G2/M arrest and mitotic catastrophe.
Zhang et al.
The citations listed below are publications that use Tocris products. Selected citations for 8-Chloroadenosine include:
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