Chemical Name: 6-Amino-8-chloropurine riboside
Biological Activity8-Chloroadenosine is a nucleoside analog; metabolized in vivo to 8-Chloro-ATP. Incorporates into RNA during transcription and inhibits RNA synthesis. Exhibits cytotoxicity in MM.1S, RPMI-8226 and U266 cancer cell lines; induces G2/M cell cycle arrest and mitotic catastrophe in A549 and H1299 cells.
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Complete Your Research
8-Chloro-adenosine inhibits growth at least partly by interfering with actin polymerization in cultured human lung cancer cells
Gu et al.
ATP analog enhances the actions of a heat shock protein 90 inhibitor in multiple myeloma cells.
Cervantes-Gomez et al.
Exposure of human lung cancer cells to 8-chloro-adenosine induces G2/M arrest and mitotic catastrophe.
Zhang et al.
Citation for 8-Chloroadenosine
The citations listed below are publications that use Tocris products. Selected citations for 8-Chloroadenosine include:
1 Citation: Showing 1 - 1
8-Chloroadenosine Sensitivity in Renal Cell Carcinoma Is Associated with AMPK Activation and mTOR Pathway Inhibition.
Authors: Kearney Et al.
PLoS One 2015;10:e0135962
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