8-Chloroadenosine

  ( 1 citations )    
Product Datasheet
Catalog Number:4436
Chemical Name:6-Amino-8-chloropurine riboside
Product Details
Citations (1)
Reviews
Biological Activity
Nucleoside analog; metabolized in vivo to 8-Chloro-ATP. Incorporates into RNA during transcription and inhibits RNA synthesis. Exhibits cytotoxicity in MM.1S, RPMI-8226 and U266 cancer cell lines; induces G2/M cell cycle arrest and mitotic catastrophe in A549 and H1299 cells.
Technical Data
  • M.Wt:
    301.69
  • Formula:
    C10H12ClN5O4
  • Solubility:
    Soluble to 20 mM in water with gentle warming and to 100 mM in DMSO
  • Purity:
    >98
  • Storage:
    Store at -20°C
  • CAS No:
    34408-14-5
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis. All Tocris products are intended for laboratory research use only.
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Citations:

The citations listed below are publications that use Tocris products. Selected citations for 8-Chloroadenosine include:

1 Citations: Showing 1 - 1

  1. 8-Chloroadenosine Sensitivity in Renal Cell Carcinoma Is Associated with AMPK Activation and mTOR Pathway Inhibition.
    Authors: Kearney Et al.
    PLoS One  2015;10:e0135962

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