8-Chloroadenosine

Catalog # Availability Size / Price Qty
4436/10
4436/50
Cat.No. 4436 - 8-Chloroadenosine | C10H12ClN5O4 | CAS No. 34408-14-5
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Description: Cytotoxic nucleoside analog; inhibits RNA synthesis

Chemical Name: 6-Amino-8-chloropurine riboside

Purity: ≥98%

Product Details
Citations (1)
Reviews

Biological Activity

Nucleoside analog; metabolized in vivo to 8-Chloro-ATP. Incorporates into RNA during transcription and inhibits RNA synthesis. Exhibits cytotoxicity in MM.1S, RPMI-8226 and U266 cancer cell lines; induces G2/M cell cycle arrest and mitotic catastrophe in A549 and H1299 cells.

Technical Data

M.Wt:
301.69
Formula:
C10H12ClN5O4
Solubility:
Soluble to 20 mM in water with gentle warming and to 100 mM in DMSO
Purity:
≥98%
Storage:
Store at -20°C
CAS No:
34408-14-5

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis. All Tocris products are intended for laboratory research use only.

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Citation for 8-Chloroadenosine

The citations listed below are publications that use Tocris products. Selected citations for 8-Chloroadenosine include:

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