8MDP

Key Product Details

Product Description

8MDP is a potent equilibrative nucleoside transporter 1 (ENT1) inhibitor (IC₅₀ = 0.43 nM). Inhibits hENT1 and hENT2 uptake of [H³]uridine in K562 cells and K15NTD cells respectively.

Product Specifications for 8MDP

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Solubility

Preparing Stock Solutions for 8MDP

The following data is based on the product molecular weight 560.73.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:

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Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
0.2 mM	8.92 mL	44.58 mL	89.17 mL
1 mM	1.78 mL	8.92 mL	17.83 mL
2 mM	0.89 mL	4.46 mL	8.92 mL
10 mM	0.18 mL	0.89 mL	1.78 mL

Calculators

Background References

References are publications that support the biological activity of the product.

• Lin Synthesis, flow cytometric evaluation, and identification of highly potent dipyrid. analogues as equilibrative nucleoside transporter 1 inhibitors. J.Med.Chem. 2007 PMID: 17636949
• Lin Design, synthesis, and evaluation of 2-diethanolamino-4,8-diheptamethyleneimino-2-(N-aminoethyl-N-ethanolamino)-6-(N,N-diethanolamino)pyrimido[5,4-d]pyrimidine-fluorescein conjugate (8MDP-fluor), as a novel equilibrativ Bioconjug.Chem. 2011 PMID: 21539390

Product Documents for 8MDP