Allosteric inhibitor of glutaminase. Blocks Rho-GTPase-dependent transformation of fibroblasts. Suppresses breast cancer cell growth and invasive activity in vitro
. Also inhibits P-493 B lymphoma cell growth and reduces tumor size of P-493 cell xenografts in mice.
Soluble to 20 mM in DMSO
Store at -20°C
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All Tocris products are intended for laboratory research use only.
Targeting mitochondrial glutaminase activity inhibits oncogenic transformation.
Wang et al.
Cancer Cell, 2010;18:207
Mechanism by which a recently discovered allosteric inhibitor blocks glutamine metabolism in transformed cells.
Stalnecker et al.
Cancer metabolism: is glutamine sweeter than glucose?
Lu et al.
Cancer Cell, 2010;18:199