Catalog Number: 6167
Chemical Name: 6,7-Dichloro-N-cyclopentyl-4-(4-pyridinyl)-1-phthalazinamine
Biological Activity
Potent and selective SUV420H1/H2 inhibitor (IC50 values are 25 and 144 nM respectively). Exhibits 100-fold selectivity over other histone methyltransferases and non-epigenetic targets. Inhibits the di- and tri-methylation of H4K20me in multiple cell lines (IC50 < 1 μM).
Chemicalprobes.org is a portal that offers independent guidance on the selection and/or application of small molecules for research. The use of A196 is reviewed on the Chemical Probes website.
Technical Data
  • M.Wt:
    359.25
  • Formula:
    C18H16Cl2N4
  • Solubility:
    Soluble to 20 mM in DMSO
  • Purity:
    >98%
  • Storage:
    Store at +4°C
  • CAS No:
    1982372-88-2
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis. All Tocris products are intended for laboratory research use only.
Additional Information
Licensing Caveats:
This probe is supplied in conjunction with the Structural Genomics Consortium. For further characterization details, please visit the A-196 probe summary on the SGC website.
Background References
  1. The SUV4-20 inhibitor A-196 verifies a role for epigenetics in genomic integrity.
    Bromberg et al.
    Nat.C hem.Biol., 2017;13:317

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