Chemical Name: 6,7-Dichloro-N-cyclopentyl-4-(4-pyridinyl)-1-phthalazinamine
Biological ActivityA 196 is a potent and selective SUV420H1/H2 inhibitor (IC50 values are 25 and 144 nM respectively) that exhibits 100-fold selectivity over other histone methyltransferases and non-epigenetic targets. A 196 inhibits the di- and tri-methylation of H4K20me in multiple cell lines (IC50 < 1 μM).
To request the negative control for A 196, please fill out the SGC 2043 request form on the SGC website.
External Portal InformationChemicalprobes.org is a portal that offers independent guidance on the selection and/or application of small molecules for research. The use of A196 is reviewed on the Chemical Probes website.
The technical data provided above is for guidance only.
For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
A chemical biology toolbox to study protein methyltransferases and epigenetic signaling.
Scheer et al.
The SUV4-20 inhibitor A-196 verifies a role for epigenetics in genomic integrity.
Bromberg et al.
Histone H4K20 tri-methylation at late-firing origins ensures timely heterochromatin replication.
Brustel et al.
EMBO J, 2017;36:2726
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