A 196

Catalog # Availability Size / Price Qty
6167/10
6167/50

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A 196 | CAS No. 1982372-88-2 | Lysine Methyltransferase Inhibitors
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Description: Potent and selective SUV420H1/H2 inhibitor

Chemical Name: 6,7-Dichloro-N-cyclopentyl-4-(4-pyridinyl)-1-phthalazinamine

Purity: ≥98%

Product Details
Reviews

Biological Activity

A 196 is a potent and selective SUV420H1/H2 inhibitor (IC50 values are 25 and 144 nM respectively) that exhibits 100-fold selectivity over other histone methyltransferases and non-epigenetic targets. A 196 inhibits the di- and tri-methylation of H4K20me in multiple cell lines (IC50 < 1 μM).

To request the negative control for A 196, please fill out the SGC 2043 request form on the SGC website.

External Portal Information

Chemicalprobes.org is a portal that offers independent guidance on the selection and/or application of small molecules for research. The use of A196 is reviewed on the Chemical Probes website.

Technical Data

M.Wt:
359.25
Formula:
C18H16Cl2N4
Solubility:
Soluble to 20 mM in DMSO
Purity:
≥98%
Storage:
Store at +4°C
CAS No:
1982372-88-2

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.

Additional Information

Licensing Caveats:
This probe is supplied in conjunction with the Structural Genomics Consortium. For further characterization details, please visit the A-196 probe summary on the SGC website.

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