A 205804

Tocris Bioscience | Catalog # 2524

Selective inhibitor of E-selectin and ICAM-1 expression
Tocris Bioscience

Key Product Details

Description

Selective inhibitor of E-selectin and ICAM-1 expression
View all Cell Adhesion Inhibitors »

Product Description

A 205804 is a selective inhibitor of E-selectin and ICAM-1 expression (IC50 values are 20, 25 and > 1000 nM for TNF-α-induced E-selectin, ICAM-1 and VCAM-1 expression respectively). Effective inhibitor of cell-cell adhesion in an in vitro flow experiment.

Product Specifications for A 205804

Molecular Weight

300.39

Formula

C15H12N2OS2

Storage

Store at +4°C

Purity

≥98% (HPLC)

Chemical Name

4-[(4-Methylphenyl)thio]thieno[2,3-c]pyridine-2-carboxamide

CAS Number

251992-66-2

PubChem ID

9839311

InChI Key

QQGWEXFLMJGCAL-UHFFFAOYSA-N

SMILES

CC1=CC=C(SC2=C3C=C(SC3=CN=C2)C(N)=O)C=C1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Solubility

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
DMSO 30.04 100
Ethanol 3 10

Preparing Stock Solutions for A 205804

The following data is based on the product molecular weight 300.39.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 3.33 mL 16.65 mL 33.29 mL
5 mM 0.67 mL 3.33 mL 6.66 mL
10 mM 0.33 mL 1.66 mL 3.33 mL
50 mM 0.07 mL 0.33 mL 0.67 mL

Calculators

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Product Documents for A 205804

Certificate of Analysis

To download a Certificate of Analysis, please enter a lot or batch number in the search box below.

Product Specific Notices for A 205804

For research use only

Customer Reviews for A 205804 (1)

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  • ICAM-1 inhibitor A 205804 show the highest increase in matrix copy number
    Name: Anonymous
    Species: Human
    Assay Type: In Vitro
    Cell Line/Tissue: HBEpC
    Verified Customer | Posted 10/20/2019
    We used different concentrations(0–100ng/mL )of the ICAM-1 inhibitor A 205804(TOCRIS),whereas 50ng/mL showed the highest(100%) increase in matrix copy number compared to the DMSO treated control cells infected with influenza virus
    A 205804 2524

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