Chemical Name: 4-[(4-Methylphenyl)thio]thieno[2,3-c]pyridine-2-carboxamide
Biological ActivitySelective inhibitor of E-selectin and ICAM-1 expression (IC50 values are 20, 25 and > 1000 nM for TNF-α-induced E-selectin, ICAM-1 and VCAM-1 expression respectively). Effective inhibitor of cell-cell adhesion in an in vitro flow experiment.
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Discovery of inhibitors of cell adhesion molecule expression in human endothelial cells. 1. Selective inhibition of ICAM-1 and E-selectin expression.
Stewart et al.
Selective inhibition of ICAM-1 and E-selectin expression in human endothelial cells. 2. Aryl modifications of 4-(aryloxy)thieno[2,3-c]pyridines with fine-tuning at C-2 carbamides.
Zhu et al.
Synthesis and mode of action of 125I- and 3H-labeled thieno[2,3-c]pyridine antagonists of cell adhesion molecule expression.
Zhu et al.
Citation for A 205804
The citations listed below are publications that use Tocris products. Selected citations for A 205804 include:
1 Citation: Showing 1 - 1
ICAM-1 regulates the survival of influenza virus in lung epithelial cells during the early stages of infection.
Authors: Othumpangat Et al.
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We used different concentrations(0–100ng/mL )of the ICAM-1 inhibitor A205804(TOCRIS),whereas 50ng/mL showed the highest(100%)increase in matrix copy number compared to the DMSO treatedcontrol cells infected with influenza virus