A 205804

Catalog # Availability Size / Price Qty
2524/10
2524/50
Cell Adhesion Inhibitors Small Molecule
1 Image
Description: Selective inhibitor of E-selectin and ICAM-1 expression

Chemical Name: 4-[(4-Methylphenyl)thio]thieno[2,3-c]pyridine-2-carboxamide

Purity: ≥98%

Product Details
Citations (1)
Supplemental Products
Reviews (1)

Biological Activity

Selective inhibitor of E-selectin and ICAM-1 expression (IC50 values are 20, 25 and > 1000 nM for TNF-α-induced E-selectin, ICAM-1 and VCAM-1 expression respectively). Effective inhibitor of cell-cell adhesion in an in vitro flow experiment.

Technical Data

M.Wt:
300.39
Formula:
C15H12N2OS2
Solubility:
Soluble to 100 mM in DMSO and to 10 mM in ethanol
Purity:
≥98%
Storage:
Store at +4°C
CAS No:
251992-66-2

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.

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Citation for A 205804

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ICAM-1 inhibitor A 205804 show the highest increase in matrix copy number
By Anonymous on 10/20/2019
Species: Human

We used different concentrations(0–100ng/mL )of the ICAM-1 inhibitor A205804(TOCRIS),whereas 50ng/mL showed the highest(100%)increase in matrix copy number compared to the DMSO treatedcontrol cells infected with influenza virus

PMID: 26499045

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