Home / Integrin Receptor Inhibitors / A 286982

A 286982

4228 1 Review Datasheet / COA / SDS
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4228/10
4228/50
A 286982 | CAS No. 280749-17-9 | Integrin Receptor Inhibitors
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Description: Potent inhibitor of the LFA-1/ICAM-1 interaction

Chemical Name: (2E)-1-(4-Acetyl-1-piperazinyl)-3-[4-[[2-(1-methylethyl)phenyl]thio]-3-nitrophenyl]-2-propen-1-one

Purity: ≥99%

Product Details
Supplemental Products
Reviews (1)
Biological Activity Technical Data Background Product Datasheets Calculators

Biological Activity

A 286982 is a potent inhibitor of the LFA-1/ICAM-1 interaction (IC50 values are 44 and 35 nM in LFA-1/ICAM-1 binding and LFA-1-mediated cell adhesion assays respectively).

Technical Data

M.Wt:
453.55
Formula:
C24H27N3O4S
Solubility:
Soluble to 100 mM in DMSO and to 50 mM in ethanol
Purity:
≥99%
Storage:
Store at RT
CAS No:
280749-17-9

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.

Product Datasheets

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VersaClone cDNA Plasmids

Human ICAM-1/CD54 (NP_000192) VersaClone cDNA

RDC1030
1 Citations

Human Integrin beta 2/CD18 (NP_000202) VersaClone cDNA

RDC0398

Mouse ICAM-1/CD54 (NP_034623) VersaClone cDNA

RDC1449

Mouse Integrin beta 2/CD18 (NP_032430) VersaClone cDNA

RDC1476

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A 286982 was used to inhibit the action of LFA-1 ( alpha L beta 2) and measure effects
By Anonymous on 02/26/2019
Application: Species: Human

alpha L beta 2 is crucial for lymphocyte adhesion and costimulation. We worked to determine alpha L beta 2's role in leukocyte adhesion to and migration through endothelium by its ability to bind intercellular adhesion molecules (ICAMs). A 286982 was used to inhibit the action and measure effects.

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