A 331440 dihydrochloride

Catalog # Availability Size / Price Qty
4697/10
4697/50
A 331440 dihydrochloride | CAS No. 1049740-32-0 | Histamine H3 Receptor Antagonists
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Description: Selective H3 antagonist

Chemical Name: 4'-[3-[(3R)-3-(Dimethylamino)-1-pyrrolidinyl]propoxy]-[1,1'-biphenyl]-4-carbonitrile dihydrochloride

Purity: ≥98%

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Biological Activity

High affinity histamine H3 receptor antagonist (Ki values are 21.7 and 22.7 nM for rat and human H3 receptors, respectively). Exhibits selectivity for human H3 over H1, H2 and H4 receptors (Ki values are 2940, 14400 and >10000 nM respectively). Shown to reduce weight in a diet-induced obesity model.

Technical Data

M.Wt:
422.39
Formula:
C22H27N3O.2HCl
Solubility:
Soluble to 100 mM in water and to 20 mM in DMSO
Purity:
≥98%
Storage:
Desiccate at RT
CAS No:
1049740-32-0

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.

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