A 331440 dihydrochloride

Key Product Details

Product Description

A 331440 dihydrochloride is a high affinity histamine H₃ receptor antagonist (K_i values are 21.7 and 22.7 nM for rat and human H₃ receptors, respectively). Exhibits selectivity for human H₃ over H₁, H₂ and H₄ receptors (K_i values are 2940, 14400 and >10000 nM respectively). Shown to reduce weight in a diet-induced obesity model.

Product Specifications for A 331440 dihydrochloride

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Solubility

Preparing Stock Solutions for A 331440 dihydrochloride

The following data is based on the product molecular weight 422.39.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:

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Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	2.37 mL	11.84 mL	23.67 mL
5 mM	0.47 mL	2.37 mL	4.73 mL
10 mM	0.24 mL	1.18 mL	2.37 mL
50 mM	0.05 mL	0.24 mL	0.47 mL

Calculators

Background References

References are publications that support the biological activity of the product.

• Hancock In vitro optimization of structure activity relationships by analogues of A-331440 combining radioligand receptor binding assays and micronucleus assays of potential antiobesity histamine H₃ receptor antagonists. Basic Clin.Pharmacol.Toxicol. 2004 PMID: 15447739
• Hancock Antiobesity effects of A-331440, a novel non-imidazole histamine H₃ receptor antagonist. Eur.J.Pharmacol. 2004 PMID: 15033391

Product Documents for A 331440 dihydrochloride