A 410099.1, amine
Chemical Name: tert-Butyl [(S)-1-[[(S)-2-[(2S,4S)-4-amino-2-[[(R)-1,2,3,4-tetrahydronaphthalen-1-yl]carbamoyl]pyrrolidin-1-yl]-1-cyclohexyl-2-oxoethyl]amino]-1-oxopropan-2-yl](methyl)carbamate hydrochloride
Biological ActivityA 410099.1, amine is a functionalized IAP ligand for PROTAC® research and development. Boc protected A 410099.1 (Cat.No. 6470). Supplied with an amine functional handle for ready conjugation to a linker/target protein ligand. Part of a range of functionalized tool molecules for PROTAC R&D.
PROTAC® is a registered trademark of Arvinas Operations, Inc., and is used under license.
Usage GuidelinesThis product is provided for use in onward chemistry. Suitable solvents can be used.
The technical data provided above is for guidance only.
For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
PROTAC-mediated degradation of Bruton's tyrosine kinase is inhibited by covalent binding.
Tinworth et al.
ACS Chem.Biol., 2019;14:342
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