Selective agonist for the dopamine D4
values are 7.9 and 12.1 nM for human D4
and rat D4
receptors). Displays no affinity (<1000 nM) for other dopamine receptors. Shows efficacy in rat models of ADHD and short-term memory.
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All Tocris products are intended for laboratory research use only.
A-412997, a selective dopamine D4 agonist, improves cognitive performance in rats.
Browman et al.
Discovery of 3-methyl-N-(1-oxy-3',4',5',6'-tetrahydro-2'H-[2,4'-bipyridine]-1'-ylmethyl)benzamide (ABT-670), an orally bioavailable dopamine D4 agonist for the treatment of erectile dysfunction.
Patel et al.
A-412997 is a selective dopamine D4 receptor agonist in rats.
Moreland et al.