A 412997 dihydrochloride

Key Product Details

Product Description

A 412997 dihydrochloride is a selective agonist for the dopamine D₄ receptor (K_i values are 7.9 and 12.1 nM for human D₄ and rat D₄ receptors). Displays no affinity (<1000 nM) for other dopamine receptors. Shows efficacy in rat models of ADHD and short-term memory.

Product Specifications for A 412997 dihydrochloride

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Solubility

Preparing Stock Solutions for A 412997 dihydrochloride

The following data is based on the product molecular weight 382.33.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:

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Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	2.62 mL	13.08 mL	26.16 mL
5 mM	0.52 mL	2.62 mL	5.23 mL
10 mM	0.26 mL	1.31 mL	2.62 mL
50 mM	0.05 mL	0.26 mL	0.52 mL

Calculators

Background References

References are publications that support the biological activity of the product.

• Patel Discovery of 3-methyl-N-(1-oxy-3',4',5',6'-tetrahydro-2'H-[2,4'-bipyridine]-1'-ylmethyl)benzamide (ABT-670), an orally bioavailable DA D₄ agonist for the treatment of erectile dysfunction. J.Med.Chem. 2006 PMID: 17149874
• Moreland A-412997 is a selective DA D₄ receptor agonist in rats. Pharmacol.Biochem.Behav. 2005 PMID: 16153699
• Browman A-412997, a selective DA D₄ agonist, improves cognitive performance in rats. Pharmacol.Biochem.Behav. 2005 PMID: 16154186

Product Documents for A 412997 dihydrochloride