A 412997 dihydrochloride
Chemical Name: N-(3-Methylphenyl)-4-(2-pyridinyl)-1-piperidineacetamide
Biological ActivitySelective agonist for the dopamine D4 receptor (Ki values are 7.9 and 12.1 nM for human D4 and rat D4 receptors). Displays no affinity (<1000 nM) for other dopamine receptors. Shows efficacy in rat models of ADHD and short-term memory.
The technical data provided above is for guidance only.
For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
A-412997 is a selective DA D4 receptor agonist in rats.
Moreland et al.
A-412997, a selective DA D4 agonist, improves cognitive performance in rats.
Browman et al.
Discovery of 3-methyl-N-(1-oxy-3',4',5',6'-tetrahydro-2'H-[2,4'-bipyridine]-1'-ylmethyl)benzamide (ABT-670), an orally bioavailable DA D4 agonist for the treatment of erectile dysfunction.
Patel et al.
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