A 419259 trihydrochloride

Tocris Bioscience | Catalog # 3914

Inhibitor of Src family kinases
Tocris Bioscience

Key Product Details

Description

Inhibitor of Src family kinases
View all Src Family Kinase Inhibitors »

Product Description

A 419259 trihydrochloride is a potent Hck inhibitor (IC50 = 0.43 nM). Also inhibits other Src family kinases (SFKs). Suppresses proliferation and induces apoptosis in CML cell lines including CD34+. Also inhibits acute myeloid leukemia (AML) stem cell proliferation in vitro and in vivo.

Product Specifications for A 419259 trihydrochloride

Molecular Weight

592.01

Formula

C29H34N6O.3HCl

Storage

Desiccate at RT

Purity

≥98% (HPLC)

Chemical Name

7-[trans-4-(4-Methyl-1-piperazinyl)cyclohexyl]-5-(4-phenoxyphenyl)-7H-Pyrrolo[2,3-d]pyrimidin-4-amine trihydrochloride

CAS Number

1435934-25-0

PubChem ID

76848881

InChI Key

ALRMEQIQFCUAMR-UHFFFAOYSA-N

SMILES

NC1=C2C(N([C@H]5CC[C@H](N6CCN(C)CC6)CC5)C=C2C3=CC=C(OC4=CC=CC=C4)C=C3)=NC=N1.Cl.Cl.Cl

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Solubility

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
water 59.2 100
DMSO 11.84 20

Preparing Stock Solutions for A 419259 trihydrochloride

The following data is based on the product molecular weight 592.01.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.69 mL 8.45 mL 16.89 mL
5 mM 0.34 mL 1.69 mL 3.38 mL
10 mM 0.17 mL 0.84 mL 1.69 mL
50 mM 0.03 mL 0.17 mL 0.34 mL

Calculators

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Background References

References are publications that support the biological activity of the product. See our Citations tab to view 14 publications citing the usage of this product.

Product Documents for A 419259 trihydrochloride

Certificate of Analysis

To download a Certificate of Analysis, please enter a lot or batch number in the search box below.

Product Specific Notices for A 419259 trihydrochloride

For research use only

Citations for A 419259 trihydrochloride

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  • Generation of EPS-blastoids
    Name: Anonymous
    Species: Mouse
    Assay Type: In Vitro
    Cell Line/Tissue: EPS
    Verified Customer | Posted 02/27/2020
    0.3uM
    A 419259 trihydrochloride 3914

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