A 419259 trihydrochloride
Chemical Name: 7-[trans-4-(4-Methyl-1-piperazinyl)cyclohexyl]-5-(4-phenoxyphenyl)-7H-Pyrrolo[2,3-d]pyrimidin-4-amine trihydrochloride
Biological ActivityA 419259 trihydrochloride is a potent Hck inhibitor (IC50 = 0.43 nM). Also inhibits other Src family kinases (SFKs). Suppresses proliferation and induces apoptosis in CML cell lines including CD34+. Also inhibits acute myeloid leukemia (AML) stem cell proliferation in vitro and in vivo.
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Tocris products are intended for laboratory research use only, unless stated otherwise.
A pyrrolo-pyrimidine derivative targets human primary AML stem cells in vivo.
Saito et al.
Selective pyrrolo-pyrimidine inhibitors reveal a necessary role for Src family kinases in Bcr-Abl signal transduction and oncogenesis.
Wilson et al.
An inhibitor-resistant mutant of Hck protects CML cells against the antiproliferative and apoptotic effects of the broad spectrum Src family kinase inhibitor A-419259.
Pene-Dumitrescu et al.
Citations for A 419259 trihydrochloride
The citations listed below are publications that use Tocris products. Selected citations for A 419259 trihydrochloride include:
2 Citations: Showing 1 - 2
Establishment of porcine and human expanded potential stem cells.
Authors: Gao Et al.
Nat Cell Bio 2019;21:687
Generation of blastocyst-like structures from mouse embryonic and adult cell cultures.
Authors: Li Et al.
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