Potent Hck inhibitor (IC50
= 0.43 nM). Also inhibits other Src family kinases (SFKs). Suppresses proliferation and induces apoptosis in CML cell lines including CD34+
. Also inhibits acute myeloid leukemia (AML) stem cell proliferation in vitro
and in vivo
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All Tocris products are intended for laboratory research use only.
Selective pyrrolo-pyrimidine inhibitors reveal a necessary role for Src family kinases in Bcr-Abl signal transduction and oncogenesis.
Wilson et al.
An inhibitor-resistant mutant of Hck protects CML cells against the antiproliferative and apoptotic effects of the broad spectrum Src family kinase inhibitor A-419259.
Pene-Dumitrescu et al.
A pyrrolo-pyrimidine derivative targets human primary AML stem cells in vivo.
Saito et al.