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A-7 hydrochloride

Catalog #: 0378 Datasheet / COA / SDS

Discontinued Product

0378 has been discontinued.
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A-7 hydrochloride | CAS No. 79127-24-5 | Calcium Binding Protein Modulator Antagonists
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Description: Calmodulin antagonist

Chemical Name: N-(10-Aminodecyl)-5-chloro-1-naphthalenesulfonamide hydrochloride

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Biological Activity

A-7 hydrochloride is a potent calmodulin antagonist (inhibits calmodulin-activated PDE activity with an IC50 of 3 μM).

Technical Data

M.Wt:
433.44
Formula:
C20H29ClN2O2S.HCl
Solubility:
Soluble to 50 mM in DMSO
Storage:
Store at RT
CAS No:
79127-24-5

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.

Background References

  1. High-throughput genotoxicity assay identifies antioxidants as inducers of DNA damage response and cell death.
    Fox JT, Sakamuru S, Huang R
    Proc. Natl. Acad. Sci. U.S.A., 2012;109(14):5423-8.
  2. Direct interaction of calmodulin antagonists with Ca2+/calmodulin-dependent cyclic nucleotide phosphodiesterase.
    Itoh and Hidaka
    J.Biochem., 1984;96:1721
  3. Naphthalenesulfonamides as calmodulin antagonists.
    Hidaka and Tanaka
    Methods Enzymol., 1983;102:185

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