A 71915
Purity: ≥95%
Biological Activity
A 71915 is a highly potent and competitive natriuretic peptide receptor A (NPRA) antagonist (pKi = 9.18). Reduces brain natriuretic peptide (BNP, Cat. No. 3522)-induced scratching in mice.Technical Data
(Modifications: X-3 = Cha, X-11= D-Tic, Cys-13 = C-terminal amide, Disulfide bridge: 2-13)
The technical data provided above is for guidance only.
For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Complete Your Research
Background References
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Discovery of a potent atrial natriuretic peptide antagonist for ANPA receptors in the human neuroblastoma NB-OK-1 cell line.
Delporte et al.
Eur.J.Pharmacol., 1992;224:183 -
Functional and pharmacological characterization of the natriuretic peptide-dependent lipolytic pathway in human fat cells.
Moro et al.
J.Pharmacol.Exp.Ther., 2004;308:984 -
Spinal functions of B-type natriuretic peptide, gastrin-releasing peptide, and their cognate receptors for regulating itch in mice.
Kiguchi et al.
J.Pharmacol.Exp.Ther., 2016;356:596
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