A 71915

Name: A 71915
Brand: Tocris Bioscience
SKU: 6715
Price: 214 USD
Availability: InStock

Tocris Bioscience | Catalog # 6715

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Citations (2)

Product Documents

Highly potent and competitive NPRA antagonist

Product Description
Product Specifications
Solubility
Calculators
Background References
Product Documents
Specific Notices

Key Product Details

Description

Highly potent and competitive NPRA antagonist

View all Natriuretic Peptide Receptor Antagonists »

Product Description

A 71915 is a highly potent and competitive natriuretic peptide receptor A (NPRA) antagonist (pK_i = 9.18). Reduces brain natriuretic peptide (BNP, Cat. No. 3522)-induced scratching in mice.

Product Specifications for A 71915

Molecular Weight

1613.95

Formula

C₆₉H₁₁₆N₂₆O₁₅S₂

Storage

Store at -20°C

Purity

≥95% (HPLC)

CAS Number

132956-87-7

PubChem ID

25083020

InChI Key

TZQXLCWSYQJGKV-YGLLJKSHSA-N

SMILES

CC[C@H](C)[C@@H]1NC(=O)[C@@H](CCCN=C(N)N)NC(=O)CNC(=O)CNC(=O)[C@H](CC2CCCCC2)NC(=O)[C@H](CSS[C@H](CCCN=C(N)N)[C@H](NC(=O)CNC(=O)[C@H]2CC3=CC=CC=C3CN2C(=O)[C@@H](NC(=O)[C@H](CCCN=C(N)N)NC(=O)[C@H](CC(O)=O)NC1=O)[C@@H](C)CC)C(N)=O)NC(=O)[C@@H](N)CCCN=C(N)N

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Solubility

Soluble to 1mg/ml in water

Calculators

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Background References

References are publications that support the biological activity of the product.

Moro Functional and pharmacological characterization of the natriuretic peptide-dependent lipolytic pathway in human fat cells. J.Pharmacol.Exp.Ther. 2004 PMID: 14634036
Kiguchi Spinal functions of B-type natriuretic peptide, gastrin-releasing peptide, and their cognate receptors for regulating itch in mice. J.Pharmacol.Exp.Ther. 2016 PMID: 26669425
Delporte Discovery of a potent atrial natriuretic peptide antagonist for ANPA receptors in the human neuroblastoma NB-OK-1 cell line. Eur.J.Pharmacol. 1992 PMID: 1334838

Product Documents for A 71915

Certificate of Analysis

To download a Certificate of Analysis, please enter a lot or batch number in the search box below.

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Product Specific Notices for A 71915

For research use only

Citations for A 71915

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