A 77-01

Catalog # Availability Size / Price Qty
A 77-01 | CAS No. 607737-87-1 | TGF-beta Receptor Inhibitors
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Description: Potent inhibitor of TGF-βRI

Chemical Name: 4-[3-(6-Methyl-2-pyridinyl)-1H-pyrazol-4-yl]quinoline

Product Details

Biological Activity

Potent TGF-βRI (ALK-5) inhibitor (IC50 = 34 nM). Inhibits TGF-β transcriptional activation. Inhibits TGF-β-induced proliferation of lung epithelial cells and SMAD phosphorylation. Inhibits TGF-β-induced epithelial-to-mesenchymal transition (EMT). Also inhibitor of p38 MAPK. Likely active metabolite of A 83-01 (Cat. No. 2939).

Technical Data

Soluble to 100 mM in DMSO and to 50 mM in 1eq. HCl
Store the unopened product at 2 - 8 °C. Do not use past expiration date.

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.

Product Datasheets

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