A 779

Name: A 779
Brand: Tocris Bioscience
SKU: 5937
Price: 112 USD
Availability: InStock

Tocris Bioscience | Catalog # 5937

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Citations (16)

Product Documents

Selective Mas receptor (Ang-(1-7) receptor) antagonist

Product Description
Product Specifications
Solubility
Calculators
Background References
Product Documents
Specific Notices

Key Product Details

Description

Selective Mas receptor (Ang-(1-7) receptor) antagonist

View all Other Angiotensin Receptors »

Product Description

A 779 is a selective Mas receptor (Ang-(1-7) receptor) antagonist. Exhibits no significant affinity for AT₁ or AT₂ receptors at a concentration of 1 μM. Inhibits antidiuretic effect of Ang-(1-7) in water-loaded rats. Also attenuates Monocrotaline-induced pulmonary fibrosis in rats.

Product Specifications for A 779

Molecular Weight

872.98

Formula

C₃₉H₆₀N₁₂O₁₁

Storage

Store at -20°C

Purity

≥95% (HPLC)

CAS Number

159432-28-7

PubChem ID

10169886

InChI Key

GZSZZUXDAPDPOR-NGIFJXEWSA-N

SMILES

[H]N[C@@H](CC(O)=O)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](CC1=CC=C(O)C=C1)C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](CC1=CNC=N1)C(=O)N[C@H](C)C(O)=O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Solubility

Soluble to 1mg/ml in water

Calculators

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Mass

Concentration

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Background References

References are publications that support the biological activity of the product. See our Citations tab to view 16 publications citing the usage of this product.

Becker Cardiovascular effects of angiotensin II and angiotensin-(1-7) at the RVLM of trained normotensive rats. Brain Res. 2005 PMID: 15804433
Santos Characterization of a new angiotensin antagonist selective for angiotensin-(1-7): evidence that the actions of angiotensin-(1-7) are mediated by specific angiotensin receptors. Brain Res.Bull. 1994 PMID: 7850477
Bruce Selective activation of angiotensin AT2 receptors attenuates progression of pulmonary hypertension and inhibits cardiopulmonary fibrosis. Br.J.Pharmacol. 2015 PMID: 25522140

Product Documents for A 779

Certificate of Analysis

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Product Specific Notices for A 779

For research use only

Citations for A 779

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