Selective Mas receptor (Ang-(1-7) receptor) antagonist. Exhibits no significant affinity for AT1
receptors at a concentration of 1 μ
M. Inhibits antidiuretic effect of Ang-(1-7) in water-loaded rats. Also attenuates Monocrotaline-induced pulmonary fibrosis in rats.
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Selective activation of angiotensin AT2 receptors attenuates progression of pulmonary hypertension and inhibits cardiopulmonary fibrosis.
Bruce et al.
Cardiovascular effects of angiotensin II and angiotensin-(1-7) at the RVLM of trained normotensive rats.
Becker et al.
Brain Res., 2005;1040:121
Characterization of a new angiotensin antagonist selective for angiotensin-(1-7): evidence that the actions of angiotensin-(1-7) are mediated by specific angiotensin receptors.
Santos et al.
Brain Res.Bull., 1994;35:293