Biological ActivityA 779 is a selective Mas receptor (Ang-(1-7) receptor) antagonist. Exhibits no significant affinity for AT1 or AT2 receptors at a concentration of 1 μM. Inhibits antidiuretic effect of Ang-(1-7) in water-loaded rats. Also attenuates Monocrotaline-induced pulmonary fibrosis in rats.
(Modifications: Ala-7 = D-Ala)
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Selective activation of angiotensin AT2 receptors attenuates progression of pulmonary hypertension and inhibits cardiopulmonary fibrosis.
Bruce et al.
Cardiovascular effects of angiotensin II and angiotensin-(1-7) at the RVLM of trained normotensive rats.
Becker et al.
Brain Res., 2005;1040:121
Characterization of a new angiotensin antagonist selective for angiotensin-(1-7): evidence that the actions of angiotensin-(1-7) are mediated by specific angiotensin receptors.
Santos et al.
Brain Res.Bull., 1994;35:293
Citations for A 779
The citations listed below are publications that use Tocris products. Selected citations for A 779 include:
2 Citations: Showing 1 - 2
Angiotensinergic receptors in the medial amygdaloid nucleus differently modulate behavioral responses in the elevated plus-maze and forced swimming test in rats.
Authors: Moreno-Santos Et al.
Behav.Brain Res. 2021;397
Angiotensin 1-7 modulates molecular and cellular processes central to the pathogenesis of prostate cancer.
Authors: Dominska Et al.
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