A 80426 mesylate
Chemical Name: N-Methyl-N-[[(1R)-1,2,3,4-tetrahydro-5-methoxy-1-naphthalenyl]methyl]-6-benzofuranethanamine mesylate
Biological ActivityHigh affinity α2-adrenoceptor antagonist and selective 5-HT uptake inhibitor (Ki values are 2.01 and 3.77 nM respectively). Displays low affinity at a variety of structurally homologous GPCRs.
The technical data provided above is for guidance only.
For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Synthesis and pharmacological characterisation of A-80426: a putative novel antidepressant combining α-2 antagonism with 5-HT uptake inhibition.
Meyer et al.
A-80426, a potent and selective β2-adrenoceptor antagonist with serotonin uptake-blocking activity and putative antidepressant-like effects: II. Pharmacology profile.
Giardina et al.
Drug Devel.Res., 1995;35:246
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