High affinity α2
-adrenoceptor antagonist and selective 5-HT uptake inhibitor (Ki
values are 2.01 and 3.77 nM respectively). Displays low affinity at a variety of structurally homologous GPCRs.
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All Tocris products are intended for laboratory research use only.
Synthesis and pharmacological characterisation of A-80426: a putative novel antidepressant combining α-2 antagonism with 5-HT uptake inhibition.
Meyer et al.