antagonist; blocks BzATP-evoked calcium influx at recombinant human, rat and mouse P2X7
values are 20, 42 and 150 nM respectively). Displays antinociceptive effects in rat and mice models of inflammatory pain. CNS penetrant.
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
The antihyperalgesic activity of a selective P2X7 receptor antagonist, A-839977, is lost in IL-1αβ knockout mice.
Honore et al.
Recent patents on novel P2X7 receptor antagonists and their potential for reducing central nervous system inflammation.
Friedle et al.
Recent Pat.CNS Drug Discov., 2010;5:35
The citations listed below are publications that use Tocris products. Selected citations for A 839977 include:
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