A 839977

Catalog # Availability Size / Price Qty
4232/10
4232/50
P2X Receptor Antagonists Small Molecule
1 Image
Description: Potent P2X7 antagonist

Chemical Name: 1-(2,3-Dichlorophenyl)-N-[[2-(2-pyridinyloxy)phenyl]methyl]-1H-tetrazol-5-amine

Purity: ≥98%

Product Details
Citations (1)
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Biological Activity

Potent P2X7 antagonist; blocks BzATP-evoked calcium influx at recombinant human, rat and mouse P2X7 receptors (IC50 values are 20, 42 and 150 nM respectively). Displays antinociceptive effects in rat and mice models of inflammatory pain. CNS penetrant.

Technical Data

M.Wt:
413.26
Formula:
C19H14Cl2N6O
Solubility:
Soluble to 100 mM in DMSO
Purity:
≥98%
Storage:
Store at +4°C
CAS No:
870061-27-1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.

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Citation for A 839977

The citations listed below are publications that use Tocris products. Selected citations for A 839977 include:

1 Citation: Showing 1 - 1

  1. Caveolin-1 regulates P2X7 receptor signaling in osteoblasts.
    Authors: Gangadharan Et al.
    PLoS One  2015;308:C41

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