A 844606

Tocris Bioscience | Catalog # 4477

Selective α7 nAChR partial agonist
Tocris Bioscience
Discontinued Product
4477 has been discontinued. View all Nicotinic (a7) Receptor Agonists products.

Key Product Details

Description

Selective α7 nAChR partial agonist
View all Nicotinic (a7) Receptor Agonists »

Product Description

A 844606 is a selective α7 nicotinic acetylcholine receptor (nAChR) partial agonist (EC50 values are 1.4 and 2.2 μM at human and rat receptors respectively). Displays no measurable effect on α4β2 nAChRs. Stimulates α7 nAChR-induced ERK1/2 phosphorylation in PC12 cells.

Product Specifications for A 844606

Molecular Weight

320.38

Formula

C20H20N2O2

Storage

Store at -20°C

Purity

≥99% (HPLC)

Chemical Name

2-(Hexahydro-5-methylpyrrolo[3,4-c]pyrrol-2(1H)-yl)-9H-xanthen-9-one

CAS Number

861119-08-6

PubChem ID

11461365

InChI Key

WUJHMDPPANTBTQ-UHFFFAOYSA-N

SMILES

O=C2C3=C(C=CC(N4CC(CN(C)C5)C5C4)=C3)OC1=CC=CC=C12

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Solubility

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
Ethanol 1.6 5 with gentle warming

Preparing Stock Solutions for A 844606

The following data is based on the product molecular weight 320.38.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.05 mM 62.43 mL 312.13 mL 624.26 mL
0.25 mM 12.49 mL 62.43 mL 124.85 mL
0.5 mM 6.24 mL 31.21 mL 62.43 mL
2.5 mM 1.25 mL 6.24 mL 12.49 mL

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Background References

References are publications that support the biological activity of the product.

Product Documents for A 844606

Certificate of Analysis

To download a Certificate of Analysis, please enter a lot or batch number in the search box below.

Product Specific Notices for A 844606

For research use only

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