7 nicotinic acetylcholine receptor (nAChR) partial agonist (EC50
values are 1.4 and 2.2 μ
M at human and rat receptors respectively). Displays no measurable effect on α
2 nAChRs. Stimulates α
7 nAChR-induced ERK1/2 phosphorylation in PC12 cells.
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Alpha7 nicotinic acetylcholine receptor agonist properties of tilorone and related tricyclic analogues.
Briggs et al.