Catalog Number: 4249
Chemical Name: 5-(4-Butoxy-3-chlorophenyl)-N-[[2-(4-morpholinyl)-3-pyridinyl]methyl-3-pyridine carboxamide
Biological Activity
Potent voltage-dependent NaV1.8 channel blocker (IC50 = 11 nM in recombinant human NaV1.8 channels). Reduces tactile allodynia in neuropathic rat models. 3- and 28-fold more potent at NaV1.8 channels compared to NaV1.2 and NaV1.7 channels respectively.
Technical Data
  • M.Wt:
    480.99
  • Formula:
    C26H29ClN4O3
  • Solubility:
    Soluble to 50 mM in DMSO
  • Purity:
    >97%
  • Storage:
    Store at RT
  • CAS No:
    1266212-81-0
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis. All Tocris products are intended for laboratory research use only.
Background References
  1. A-887826 is a structurally novel, potent and voltage-dependent NaV1.8 sodium channel blocker that attenuates neuropathic tactile allodynia in rats.
    Zhang et al.
    Neuropharmacology, 2010;59:201
Citations:

The citations listed below are publications that use Tocris products. Selected citations for A 887826 include:

1 Citations: Showing 1 - 1

  1. Injury-induced HDAC5 nuclear export is essential for axon regeneration.
    Authors: Cho Et al.
    Nat Chem Biol 2013;155:894

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