Potent voltage-dependent NaV
1.8 channel blocker (IC50
= 11 nM in recombinant human NaV
1.8 channels). Reduces tactile allodynia in neuropathic rat models. 3- and 28-fold more potent at NaV
1.8 channels compared to NaV
1.2 and NaV
1.7 channels respectively.
Soluble to 50 mM in DMSO
Store at RT
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A-887826 is a structurally novel, potent and voltage-dependent NaV1.8 sodium channel blocker that attenuates neuropathic tactile allodynia in rats.
Zhang et al.
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