Chemical Name: 5-(4-Butoxy-3-chlorophenyl)-N-[[2-(4-morpholinyl)-3-pyridinyl]methyl-3-pyridine carboxamide
Biological ActivityA 887826 is a potent voltage-dependent NaV1.8 channel blocker (IC50 = 11 nM in recombinant human NaV1.8 channels). Reduces tactile allodynia in neuropathic rat models. 3- and 28-fold more potent at NaV1.8 channels compared to NaV1.2 and NaV1.7 channels respectively.
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A-887826 is a structurally novel, potent and voltage-dependent NaV1.8 sodium channel blocker that attenuates neuropathic tactile allodynia in rats.
Zhang et al.
Citation for A 887826
The citations listed below are publications that use Tocris products. Selected citations for A 887826 include:
1 Citation: Showing 1 - 1
Injury-induced HDAC5 nuclear export is essential for axon regeneration.
Authors: Cho Et al.
Nat Chem Biol 2013;155:894
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