A 887826

Catalog # Availability Size / Price Qty
4249/10
4249/50
A 887826 | CAS No. 1266212-81-0 | Voltage-gated Sodium Channel Blockers
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Description: Potent voltage-dependent NaV1.8 channel blocker

Chemical Name: 5-(4-Butoxy-3-chlorophenyl)-N-[[2-(4-morpholinyl)-3-pyridinyl]methyl-3-pyridine carboxamide

Purity: ≥97%

Product Details
Citations (1)
Reviews

Biological Activity

Potent voltage-dependent NaV1.8 channel blocker (IC50 = 11 nM in recombinant human NaV1.8 channels). Reduces tactile allodynia in neuropathic rat models. 3- and 28-fold more potent at NaV1.8 channels compared to NaV1.2 and NaV1.7 channels respectively.

Technical Data

M.Wt:
480.99
Formula:
C26H29ClN4O3
Solubility:
Soluble to 50 mM in DMSO
Purity:
≥97%
Storage:
Store at RT
CAS No:
1266212-81-0

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.

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Citation for A 887826

The citations listed below are publications that use Tocris products. Selected citations for A 887826 include:

1 Citation: Showing 1 - 1

  1. Injury-induced HDAC5 nuclear export is essential for axon regeneration.
    Authors: Cho Et al.
    Nat Chem Biol  2013;155:894

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