A 922500

Catalog # Availability Size / Price Qty
3587/10
A 922500 | CAS No. 959122-11-3 | Diacylglycerol O-Acyltransferase (DGAT) Inhibitors
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Description: Potent DGAT-1 inhibitor
Alternative Names: DGAT-1 Inhibitor 4a

Chemical Name: (1R,2R)-2-[[4'-[[Phenylamino)carbonyl]amino] [1,1'-biphenyl]-4-yl]carbonyl]cyclopentanecarboxylic acid

Purity: ≥98%

Product Details
Citations (4)
Reviews

Biological Activity

Diacylglycerol acyltransferase 1 (DGAT-1) inhibitor (IC50 values are 7 and 24 nM at human and mouse DGAT-1 respectively) that is devoid of activity at DGAT-2, ACAT1 or ACAT2. Induces significant weight loss without altering food intake, and decreases liver and plasma triglyceride levels in vivo. Orally active.

Technical Data

M.Wt:
428.48
Formula:
C26H24N2O4
Solubility:
Soluble to 50 mM in DMSO
Purity:
≥98%
Storage:
Desiccate at +4°C
CAS No:
959122-11-3

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.

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