Chemical Name: Ethyl 2-[[3,4-dihydro-4-oxo-3-[3-(1-pyrrolidinyl)propyl]benzothieno[3,2-d]pyrimidin-2-yl]thio]acetate
Biological ActivityALDH1A1 inhibitor (IC50 = 4.6 μM; Ki = 300 nM). Exhibits selectivity for ALDH1A1 over eight other ALDH isoforms. Disrupts spheroid formation and reduces cell viability of ovarian cancer cells in vitro.
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis. All Tocris products are intended for laboratory research use only.
Characterization of two distinct structural classes of selective aldehyde dehydrogenase 1A1 inhibitors.
Morgan and Hurley
β-Catenin-regulated ALDH1A1 is a target in ovarian cancer spheroids.
Condello et al.
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