Catalog Number: 5802
Alternate Names: CM 037
Chemical Name: Ethyl 2-[[3,4-dihydro-4-oxo-3-[3-(1-pyrrolidinyl)propyl][1]benzothieno[3,2-d]pyrimidin-2-yl]thio]acetate
Biological Activity
ALDH1A1 inhibitor (IC50 = 4.6 μM; Ki = 300 nM). Exhibits selectivity for ALDH1A1 over eight other ALDH isoforms. Disrupts spheroid formation and reduces cell viability of ovarian cancer cells in vitro.
Technical Data
  • M.Wt:
    431.57
  • Formula:
    C21H25N3O3S2
  • Solubility:
    Soluble to 100 mM in DMSO and to 100 mM in ethanol
  • Purity:
    >97%
  • Storage:
    Store at +4°C
  • CAS No:
    896795-60-1
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis. All Tocris products are intended for laboratory research use only.
Background References
  1. Characterization of two distinct structural classes of selective aldehyde dehydrogenase 1A1 inhibitors.
    Morgan and Hurley
    J.Med.Chem, 2015;58:1964
  2. β-Catenin-regulated ALDH1A1 is a target in ovarian cancer spheroids.
    Condello et al.
    Oncogene, 2015;34:2297

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