ALDH1A1 inhibitor (IC50
= 4.6 μ
= 300 nM). Exhibits selectivity for ALDH1A1 over eight other ALDH isoforms. Disrupts spheroid formation and reduces cell viability of ovarian cancer cells in vitro
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Characterization of two distinct structural classes of selective aldehyde dehydrogenase 1A1 inhibitors.
Morgan and Hurley
β-Catenin-regulated ALDH1A1 is a target in ovarian cancer spheroids.
Condello et al.