Chemical Name: Ethyl 2-[[3,4-dihydro-4-oxo-3-[3-(1-pyrrolidinyl)propyl]benzothieno[3,2-d]pyrimidin-2-yl]thio]acetate
Biological ActivityALDH1A1 inhibitor (IC50 = 4.6 μM; Ki = 300 nM). Exhibits selectivity for ALDH1A1 over eight other ALDH isoforms. Disrupts spheroid formation and reduces cell viability of ovarian cancer cells in vitro.
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Tocris products are intended for laboratory research use only, unless stated otherwise.
Characterization of two distinct structural classes of selective aldehyde dehydrogenase 1A1 inhibitors.
Morgan and Hurley
β-Catenin-regulated ALDH1A1 is a target in ovarian cancer spheroids.
Condello et al.
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