AA 147

Tocris Bioscience | Catalog # 6759

ER proteostasis regulator
Tocris Bioscience

Key Product Details

Description

ER proteostasis regulator
View all Other ER Stress/UPR Activators »

Product Description

AA 147 is an endoplasmic reticulum (ER) proteostasis regulator. Activates the ATF6 transcriptional program independently of ER stress and/or global UPR activation. Selectively reduces secretion of amyloidogenic transthyretin (TTR) from HepG2 cells. Reduces amyloidogenic immunoglobulin light chain (ALLC) secretion from ALMC-2 cells (EC50 = 1.1 μM).

Product Specifications for AA 147

Molecular Weight

255.31

Formula

C16H17NO2

Storage

Store at +4°C

Purity

≥98% (HPLC)

Chemical Name

N-(2-Hydroxy-5-methylphenyl)benzenepropanamide

CAS Number

393121-74-9

PubChem ID

882909

InChI Key

AWHLTHOHBAGPMY-UHFFFAOYSA-N

SMILES

CC1=CC(NC(CCC2=CC=CC=C2)=O)=C(C=C1)O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Solubility

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
DMSO 25.53 100
Ethanol 25.53 100

Preparing Stock Solutions for AA 147

The following data is based on the product molecular weight 255.31.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 3.92 mL 19.58 mL 39.17 mL
5 mM 0.78 mL 3.92 mL 7.83 mL
10 mM 0.39 mL 1.96 mL 3.92 mL
50 mM 0.08 mL 0.39 mL 0.78 mL

Calculators

Calculate the mass, volume, or concentration required for a solution.

=
x
x
g/mol

*When preparing stock solutions always use the batch-specific molecular weight of the product found on the vial label and CoA (available online).

Calculate the dilution required to prepare a stock solution.

x
=
x

The reconstitution calculator allows you to quickly calculate the volume of a reagent to reconstitute your vial. Simply enter the mass of reagent and the target concentration and the calculator will determine the rest.

=
÷

Background References

References are publications that support the biological activity of the product. See our Citations tab to view 11 publications citing the usage of this product.

Product Documents for AA 147

Certificate of Analysis

To download a Certificate of Analysis, please enter a lot or batch number in the search box below.

Product Specific Notices for AA 147

For research use only

Customer Reviews for AA 147 (1)

5 out of 5
1 Customer Rating
5 Stars
100%
4 Stars
0%
3 Stars
0%
2 Stars
0%
1 Stars
0%

Have you used AA 147?

Submit a review and receive an Amazon gift card!

$25/€18/£15/$25CAN/¥2500 Yen for a review with an image

$10/€7/£6/$10CAN/¥1110 Yen for a review without an image

Submit a review
Amazon Gift Card

Customer Images

Showing  1 - 1 of 1 review Showing All
Filter By:
Clear Filters X
  • ATF6 activation
    Name: Anonymous
    Species: Human
    Assay Type: In Vitro
    Cell Line/Tissue: Molm13
    Verified Customer | Posted 10/30/2020
    Worked well, induced translocation of ATF to the nucleus (green in image), showing cleavage of the protein and its activation. Caused reduction of downstream inhibited genes CPT1a and PPARA in our experiments
    Used to induce activation of the ATF6 ER stress pathway
    AA 147 6759

There are no reviews that match your criteria.

Showing  1 - 1 of 1 review Showing All