Chemical Name: N-(2-Hydroxy-5-methylphenyl)benzenepropanamide
Biological ActivityEndoplasmic reticulum (ER) proteostasis regulator. Activates the ATF6 transcriptional program independently of ER stress and/or global UPR activation. Selectively reduces secretion of amyloidogenic transthyretin (TTR) from HepG2 cells. Reduces amyloidogenic immunoglobulin light chain (ALLC) secretion from ALMC-2 cells (EC50 = 1.1 μM).
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Small molecule proteostasis regulators that reprogram the ER to reduce extracellular protein aggregation.
Plate et al.
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