AA 147
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Description: ER proteostasis regulator
Chemical Name: N-(2-Hydroxy-5-methylphenyl)benzenepropanamide
Purity: ≥98%
Biological Activity
AA 147 is an endoplasmic reticulum (ER) proteostasis regulator. Activates the ATF6 transcriptional program independently of ER stress and/or global UPR activation. Selectively reduces secretion of amyloidogenic transthyretin (TTR) from HepG2 cells. Reduces amyloidogenic immunoglobulin light chain (ALLC) secretion from ALMC-2 cells (EC50 = 1.1 μM).Technical Data
M.Wt:
255.31
Formula:
C16H17NO2
Solubility:
Soluble to 100 mM in DMSO and to 100 mM in ethanol
Purity:
≥98%
Storage:
Store at +4°C
CAS No:
393121-74-9
The technical data provided above is for guidance only.
For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
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Background References
-
Small molecule proteostasis regulators that reprogram the ER to reduce extracellular protein aggregation.
Plate et al.
Elife, 2016;5:e15550
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