Positive allosteric modulator of GABAA
receptors. Modulates both α4β3δ
-containing extrasynaptic receptors and α1β3γ2S
-containing receptors in Xenopus
oocytes, displaying a stronger modulatory effect at the former. Reduces motor coordination and exhibits anxiolytic effects in vivo
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Pharmacological characterization of a novel positive modulator at α4β3δ-containing extrasynaptic GABAA receptors.
Hoestgaard-Jensen et al.