channel blocker (IC50
values are 2 and 64 μ
M at 500 nm and 380 nm respectively). Switches conformation from cis
at 500 nm and trans
at 380 nm. Exhibits minimal activity at Nav
1.2 and L-type Ca2+
channels. Stimulates action potential firing of hippocampal neurons in vitro
at 500 nm and restores visual responsiveness in blind mice at 380 nm.
Soluble to 20 mM in DMSO
Store at -20°C
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
Sold under license from Photoswitch Biosciences, Inc.
Photochemical control of endogenous ion channels and cellular excitability.
Fortin et al.
Photochemical restoration of visual responses in blind mice.
Polosukhina et al.
Photochromic blockers of voltage-gated potassium channels.
Banghart et al.