Chemical Name: N,N,N-Triethyl-2-oxo-2-[[4-[2-[4-[(1-oxo-2-propen-1-yl)amino]phenyl]diazenyl]phenylamino]ethanaminium chloride
Biological ActivityAAQ chloride is a photoswitchable Kv channel blocker (IC50 values are 2 and 64 μM at 500 nm and 380 nm respectively). Switches conformation from cis to trans at 500 nm and trans to cis at 380 nm. Exhibits minimal activity at Nav1.2 and L-type Ca2+ channels. Stimulates action potential firing of hippocampal neurons in vitro at 500 nm and restores visual responsiveness in blind mice at 380 nm.
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Complete Your Research
Photochromic blockers of voltage-gated potassium channels.
Banghart MR et al.
Photochemical control of endogenous ion channels and cellular excitability.
Fortin et al.
Photochemical restoration of visual responses in blind mice.
Polosukhina et al.
Citation for AAQ chloride
The citations listed below are publications that use Tocris products. Selected citations for AAQ chloride include:
1 Citation: Showing 1 - 1
Development of a quaternary ammonium photoswitchable antagonist of NMDA receptors.
Authors: Nikolaev Et al.
Eur J Pharmacol. 2022;
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