Abeta 40 Antibody (3D7) - Chimeric

Novus Biologicals | Catalog # NBP3-48386

Recombinant Monoclonal Antibody
Novus Biologicals
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Key Product Details

Species Reactivity

Human

Applications

Flow Cytometry

Label

Unconjugated

Antibody Source

Recombinant Monoclonal Human IgG1 Clone # 3D7
View all Abeta 40 Primary Antibodies »

Product Specifications

Immunogen

Abeta 40 recombinant protein expressed in mammalian cells (Accession# P05067). The exact amino acid sequence is proprietary.

Clonality

Monoclonal

Host

Human

Isotype

IgG1

Description

This product is shipped at ambient temperature. Store at -20C to -80C for 12 months in lyophilized form. After reconstitution, if not intended for use within a month, aliquot and store at -80C (Avoid repeated freezing and thawing).

Scientific Data Images for Abeta 40 Antibody (3D7) - Chimeric

Abeta 40 Antibody (3D7) - Chimeric

Flow Cytometry: Abeta 40 Antibody (3D7) - Chimeric [NBP3-48386]

Flow cytometry analysis of antigen binding of anti-human APP mAb(NBP3-48386). (A) NBP3-48386 does not bind to CHO-S cells that do not express APP. (B) A clear peak shift of NBP3-48386 was seen compared to the control when incubated with APP-expressing Siha cells, indicating strong binding of NBP3-48386 to APP. Antibodies were incubated at 5 ug/mL.
Abeta 40 Antibody (3D7) - Chimeric

Flow Cytometry: Abeta 40 Antibody (3D7) - Chimeric [NBP3-48386]

Flow cytometry analysis with Anti-Abeta 40 (3D7) mAb on HEK293 cells transfected with human Abeta 40 (Blue histogram) or HEK293 transfected with irrelevant protein (Red histogram).

Applications for Abeta 40 Antibody (3D7) - Chimeric

Application
Recommended Usage

Flow Cytometry

1:100

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Flow Cytometry

Formulation, Preparation, and Storage

Purification

Antigen Affinity-purified from cell culture supernatant

Reconstitution

Dissolve the lyophilized antibody in sterile and low endotoxin water. The recommend volume of water is lot specific. Please refer to the instructions printed on the product vial or contact technical support.

Formulation

PBS, pH 7.4, 5-8% Trehalose

Preservative

Trehalose

Concentration

LYOPH mg/ml

Shipping

The product is shipped at ambient temperature. Upon receipt, store it immediately at the temperature recommended below.

Stability & Storage

Store at -20C in powder form. Store at -80C once reconstituted.

Calculators

The reconstitution calculator allows you to quickly calculate the volume of a reagent to reconstitute your vial. Simply enter the mass of reagent and the target concentration and the calculator will determine the rest.

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Background: Abeta 40

Amyloid beta-protein (Abeta) is associated with neuronal injury and death in Alzheimer's disease. The most common isoforms are of Amyloid beta are Abeta40 and Abeta42.

The Amyloid beta A4 protein (Abeta40) is the more common isoform and is the main components of amyloid plaques. Abeta-40 is produced by cleavage of the Amyloid Precursor Protein (APP) that occurs in the endoplasmic reticulum.

The Amyloid beta proteins function as a cell surface receptor and supports neurite growth, neuronal adhesion and axonogenesis on the surface of neurons. Amyloid betas are also involved in cell mobility functions and transcription regulation via various protein-protein interactions.

Abeta40 antibodies are useful tools for Alzheimer's studies and research on amyloid plaques.

Alternate Names

amyloid beta 40, Beta-amyloid protein 40

Gene Symbol

APP

Additional Abeta 40 Products

Product Documents for Abeta 40 Antibody (3D7) - Chimeric

Certificate of Analysis

To download a Certificate of Analysis, please enter a lot or batch number in the search box below.

Product Specific Notices for Abeta 40 Antibody (3D7) - Chimeric

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

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