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ABT 751

4138 Datasheet / COA / SDS
Catalog # Availability Size / Price Qty
4138/10
4138/50
ABT 751 | CAS No. 141430-65-1 | Microtubule Binding Compounds
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Description: Inhibitor of microtubule polymerization; antimitotic and antitumor

Chemical Name: N-[2-[(4-Hydroxyphenyl)amino]-3-pyridinyl]-4-methoxybenzenesulfonamide

Purity: ≥98%

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Biological Activity

Antimitotic agent, inhibits microtubule polymerization. Binds to β-tubulin on the colchine site; blocks cell cycle at G2M phase and induces apoptosis. Exhibits antitumor activity. Also displays activity in cell lines resistant to vincristine, doxorubicin and cisplatin. Orally bioavailable.

Technical Data

M.Wt:
371.41
Formula:
C18H17N3O4S
Solubility:
Soluble to 100 mM in DMSO and to 25 mM in ethanol
Purity:
≥98%
Storage:
Store at +4°C
CAS No:
141430-65-1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.

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