Catalog Number: 3370
Chemical Name: (±)-(3R*,4S*)-2-Oxo-4-phenyl-3-pyrollidinecarboxylic acid 2-[1-(3-bromophenyl)ethylidene]hydrazide
Biological Activity
Potent and selective protease-activated receptor 2 (PAR2) agonist (pEC50 = 7.5). Displays no activity at other PAR subtypes and exhibits no significant activity at over 30 other receptors implicated in nociception and inflammation. Stimulates PI hydrolysis, Ca2+ mobilization and cellular proliferation in vitro (pEC50 values are 6.9, 7.0 and 7.5 respectively).
Technical Data
  • M.Wt:
    400.27
  • Formula:
    C19H18BrN3O2
  • Solubility:
    Soluble to 100 mM in DMSO
  • Purity:
    >98%
  • Storage:
    Store at -20°C
  • CAS No:
    1051487-82-1
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis. All Tocris products are intended for laboratory research use only.
Background References
  1. Discovery of potent and selective small-molecule PAR-2 agonists.
    Seitzberg et al.
    J.Med.Chem., 2008;51:5490
  2. Identification and characterization of novel small-molecule protease-activated receptor 2 agonists.
    Gardell et al.
    J.Pharmacol.Exp.Ther., 2008;327:799

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