AC 264613

Catalog # Availability Size / Price Qty
3370/10
3370/50
AC 264613 | CAS No. 1051487-82-1 | Protease-Activated Receptor Agonists
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Description: PAR2 receptor agonist

Chemical Name: (±)-(3R*,4S*)-2-Oxo-4-phenyl-3-pyrollidinecarboxylic acid 2-[1-(3-bromophenyl)ethylidene]hydrazide

Purity: ≥98%

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Biological Activity

Potent and selective protease-activated receptor 2 (PAR2) agonist (pEC50 = 7.5). Displays no activity at other PAR subtypes and exhibits no significant activity at over 30 other receptors implicated in nociception and inflammation. Stimulates PI hydrolysis, Ca2+ mobilization and cellular proliferation in vitro (pEC50 values are 6.9, 7.0 and 7.5 respectively).

Technical Data

M.Wt:
400.27
Formula:
C19H18BrN3O2
Solubility:
Soluble to 100 mM in DMSO
Purity:
≥98%
Storage:
Store at -20°C
CAS No:
1051487-82-1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.

Background References

  1. Discovery of potent and selective small-molecule PAR-2 agonists.
    Seitzberg et al.
    J.Med.Chem., 2008;51:5490
  2. Identification and characterization of novel small-molecule protease-activated receptor 2 agonists.
    Gardell et al.
    J.Pharmacol.Exp.Ther., 2008;327:799

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