AC 264613

Key Product Details

Product Description

AC 264613 is a potent and selective protease-activated receptor 2 (PAR₂) agonist (pEC₅₀ = 7.5). Displays no activity at other PAR subtypes and exhibits no significant activity at over 30 other receptors implicated in nociception and inflammation. Stimulates PI hydrolysis, Ca²⁺ mobilization and cellular proliferation in vitro (pEC₅₀ values are 6.9, 7.0 and 7.5 respectively).

Product Specifications for AC 264613

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Solubility

Preparing Stock Solutions for AC 264613

The following data is based on the product molecular weight 400.27.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:

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Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	2.50 mL	12.49 mL	24.98 mL
5 mM	0.50 mL	2.50 mL	5.00 mL
10 mM	0.25 mL	1.25 mL	2.50 mL
50 mM	0.05 mL	0.25 mL	0.50 mL

Calculators

Background References

References are publications that support the biological activity of the product. See our Citations tab to view 8 publications citing the usage of this product.

• Seitzberg Discovery of potent and selective small-molecule PAR-2 agonists. J.Med.Chem. 2008 PMID: 18720984
• Gardell Identification and characterization of novel small-molecule protease-activated receptor 2 agonists. J.Pharmacol.Exp.Ther. 2008 PMID: 18768780

Product Documents for AC 264613