Catalog Number: 6165
Chemical Name: α-(2,4-Dimethylphenyl)-α-methyl-2-benzothiazolemethanol
Biological Activity
CaSR biased allosteric modulator (pEC50 = 7.8-8.1). Calcimimetic. Displays ability to bias signalling towards the accumulation of PERK1/2 and IP1. Reduces parathyroid hormone (PTH) levels in rat serum without inducing the release of calcitonin. Exhibits no significant activation of human GABAB or type I PTH receptors. Orally active.
Technical Data
  • M.Wt:
  • Formula:
  • Solubility:
    Soluble to 100 mM in DMSO and to 100 mM in ethanol
  • Purity:
  • Storage:
    Store at +4°C
  • CAS No:
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis. All Tocris products are intended for laboratory research use only.
Background References
  1. Characterization of highly efficacious allosteric agonists of the human calcium-sensing receptor.
    Ma et al.
    J.Pharmacol.Exp.Ther., 2011;337:275
  2. Biased allosteric modulation at the CaS receptor engendered by structurally diverse calcimimetics.
    Cook et al.
    Br.J.Pharmacol., 2015;172:185
  3. Towards a structural understanding of allosteric drugs at the human calcium-sensing receptor.
    Leach et al.
    Cell.Res., 2016;26:574

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