Chemical Name: α-(2,4-Dimethylphenyl)-α-methyl-2-benzothiazolemethanol
Biological ActivityAC 265347 is a CaSR biased allosteric modulator (pEC50 = 7.8-8.1). Calcimimetic. Displays ability to bias signalling towards the accumulation of pERK1/2 and IP1. Reduces parathyroid hormone (PTH) levels in rat serum without inducing the release of calcitonin. Exhibits no significant activation of human GABAB or type I PTH receptors. Orally active.
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Tocris products are intended for laboratory research use only, unless stated otherwise.
Biased allosteric modulation at the CaS receptor engendered by structurally diverse calcimimetics.
Cook et al.
Characterization of highly efficacious allosteric agonists of the human calcium-sensing receptor.
Ma et al.
Towards a structural understanding of allosteric drugs at the human calcium-sensing receptor.
Leach et al.
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