Catalog Number: 5281
Alternate Names: XBD173
Chemical Name: N-Ethyl-7,8-dihydro-7-methyl-8-oxo-2-phenyl-N-(phenylmethyl)-9H-purine-9-acetamide
Biological Activity
Ligand of translocator protein (TSPO, peripheral benzodiazepine receptor). Exhibits high affinity for TSPO in rat whole brain (Ki = 0.297 nM), and high potency against human and rat glial TSPO (IC50 values are 2.73 and 3.04 nM respectively). Displays no noticeable binding to a number of other receptors, transporters or ion channels. Also displays anxiolytic and antidepressant effects in rodent models, without inducing benzodiazepine-like adverse effects.
Technical Data
  • M.Wt:
    401.46
  • Formula:
    C23H23N5O2
  • Solubility:
    Soluble to 100 mM in DMSO and to 10 mM in ethanol with sonication
  • Purity:
    >98%
  • Storage:
    Store at +4°C
  • CAS No:
    226954-04-7
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis. All Tocris products are intended for laboratory research use only.
Background References
  1. Antianxiety and antidepressant-like effects of AC-5216, a novel mitochondrial benzodiazepine receptor ligand.
    Kita et al.
    Br.J.Pharmacol., 2004;142:1059
  2. Repeated administration of AC-5216, a ligand for the 18kDa translocator protein, improves behavioral deficits in a mouse model of post-traumatic stress disorder.
    Qiu et al.
    Prog.Neuropsychopharmacol.Biol.Psychiatry, 2013;45:40

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