AC 55649

Key Product Details

Product Description

AC 55649 is a potent, isoform-selective RARβ2 receptor agonist (pEC₅₀ values are 6.9, 5.7 and 5.6 at RARβ2, RARβ1 and RARα respectively) that displays 100-fold selectivity versus other retinoid receptors. Inhibits proliferation of the breast cancer cell line MCF-7.

Product Specifications for AC 55649

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Solubility

Preparing Stock Solutions for AC 55649

The following data is based on the product molecular weight 310.44.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:

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Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	3.22 mL	16.11 mL	32.21 mL
5 mM	0.64 mL	3.22 mL	6.44 mL
10 mM	0.32 mL	1.61 mL	3.22 mL
50 mM	0.06 mL	0.32 mL	0.64 mL

Calculators

Background References

References are publications that support the biological activity of the product. See our Citations tab to view 4 publications citing the usage of this product.

• Lund Design, synthesis, and structure-activity analysis of isoform selective retinoic acid receptor ligands. J.Med.Chem. 2009 PMID: 19239230
• Lund Discovery of a potent, orally available, and isoform-selective retinoic acid β2 receptor agonist. J.Med.Chem. 2005 PMID: 16302793

Product Documents for AC 55649