AC 55649

  ( 5 citations )    
Product Datasheet
Catalog Number:2436
Chemical Name:4'-Octyl-[1,1'-biphenyl]-4-carboxylic acid
Product Details
Citations (5)
Reviews
Biological Activity
Potent, isoform-selective RARβ2 receptor agonist (pEC50 values are 6.9, 5.7 and 5.6 at RARβ2, RARβ1 and RARα respectively) that displays 100-fold selectivity versus other retinoid receptors. Inhibits proliferation of the breast cancer cell line MCF-7.
Technical Data
  • M.Wt:
    310.44
  • Formula:
    C21H26O2
  • Solubility:
    Soluble to 100 mM in DMSO and to 25 mM in ethanol
  • Purity:
    >99
  • Storage:
    Store at +4°C
  • CAS No:
    59662-49-6
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis. All Tocris products are intended for laboratory research use only.
Product Datasheets
Citations:

The citations listed below are publications that use Tocris products. Selected citations for AC 55649 include:

5 Citations: Showing 1 - 5
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  1. Aurora-B kinase pathway controls the lateral to end-on conversion of kinetochore-microtubule attachments in human cells.
    Authors: Shrestha Et al.
    Nat Commun  2017;8:150
  2. Human Pluripotent Stem Cell-Derived Atrial and Ventricular Cardiomyocytes Develop from Distinct Mesoderm Populations.
    Authors: Lee Et al.
    Cell Stem Cell  2017;21:179
  3. Retinoic acid receptor gamma impacts cellular adhesion, Alpha5 Beta1 integrin expression and proliferation in K562 cells.
    Authors: Kelley
    PLoS One  2017;12(5):e0178116
  4. Complementary roles of retinoic acid and TGF-β1 in coordinated expression of mucosal integrins by T cells.
    Authors: Kang Et al.
    Front Behav Neurosci  2011;4:66
  5. A comparison of the roles of peroxisome proliferator-activated receptor and retinoic acid receptor on CYP26 regulation.
    Authors: Tay Et al.
    Mol Pharmacol  2010;77:218

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