Catalog Number: 2436
Chemical Name: 4'-Octyl-[1,1'-biphenyl]-4-carboxylic acid
Biological Activity
Potent, isoform-selective RARβ2 receptor agonist (pEC50 values are 6.9, 5.7 and 5.6 at RARβ2, RARβ1 and RARα respectively) that displays 100-fold selectivity versus other retinoid receptors. Inhibits proliferation of the breast cancer cell line MCF-7.
Technical Data
  • M.Wt:
  • Formula:
  • Solubility:
    Soluble to 100 mM in DMSO and to 25 mM in ethanol
  • Purity:
  • Storage:
    Store at +4°C
  • CAS No:
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis. All Tocris products are intended for laboratory research use only.
Background References
  1. Discovery of a potent, orally available, and isoform-selective retinoic acid β2 receptor agonist.
    Lund et al.
    J.Med.Chem., 2005;48:7517
  2. Design, synthesis, and structure-activity analysis of isoform selective retinoic acid receptor ligands.
    Lund et al.
    J.Med.Chem., 2009;52:1540

The citations listed below are publications that use Tocris products. Selected citations for AC 55649 include:

Showing Results 1 - 1 of 1

  1. Complementary roles of retinoic acid and TGF-β1 in coordinated expression of mucosal integrins by T cells.
    Authors: Kang Et al.
    Front Behav Neurosci
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