Chemical Name: 4'-Octyl-[1,1'-biphenyl]-4-carboxylic acid
Biological ActivityPotent, isoform-selective RARβ2 receptor agonist (pEC50 values are 6.9, 5.7 and 5.6 at RARβ2, RARβ1 and RARα respectively) that displays 100-fold selectivity versus other retinoid receptors. Inhibits proliferation of the breast cancer cell line MCF-7.
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Tocris products are intended for laboratory research use only, unless stated otherwise.
Discovery of a potent, orally available, and isoform-selective retinoic acid β2 receptor agonist.
Lund et al.
Design, synthesis, and structure-activity analysis of isoform selective retinoic acid receptor ligands.
Lund et al.
Citations for AC 55649
The citations listed below are publications that use Tocris products. Selected citations for AC 55649 include:
5 Citations: Showing 1 - 5
Aurora-B kinase pathway controls the lateral to end-on conversion of kinetochore-microtubule attachments in human cells.
Authors: Shrestha Et al.
Nat Commun 2017;8:150
Human Pluripotent Stem Cell-Derived Atrial and Ventricular Cardiomyocytes Develop from Distinct Mesoderm Populations.
Authors: Lee Et al.
Cell Stem Cell 2017;21:179
Retinoic acid receptor gamma impacts cellular adhesion, Alpha5 Beta1 integrin expression and proliferation in K562 cells.
PLoS One 2017;12(5):e0178116
Complementary roles of retinoic acid and TGF-β1 in coordinated expression of mucosal integrins by T cells.
Authors: Kang Et al.
Front Behav Neurosci 2011;4:66
A comparison of the roles of peroxisome proliferator-activated receptor and retinoic acid receptor on CYP26 regulation.
Authors: Tay Et al.
Mol Pharmacol 2010;77:218
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