Ac4-8-keto-Neu5Ac n-pentyl ester

Tocris Bioscience | Catalog # 7922

α2,8-linked polysialic acid biosynthesis attenuator
Tocris Bioscience
100% Guarantee

Key Product Details

Description

α2,8-linked polysialic acid biosynthesis attenuator

Alternative Names

8-Keto-Neu5Ac
View all Cell Adhesion Inhibitors »

Product Description

Ac4-8-keto-Neu5Ac n-pentyl ester is a selective α2,8-linked polysialic acid biosynthesis attenuator. Acts as a chain-terminating metabolic inhibitor when incorporated in oligo- and polysialic chains, preventing chain elongation and blocking the biosynthesis of glycan polysialic acid (polySia). Does not inhibit cell surface sialylation. Displays low toxicity in MCF7 and AtT-20 cancer cell lines (EC50 = 3 and 4 mM, respectively).

Product Specifications for Ac4-8-keto-Neu5Ac n-pentyl ester

Molecular Weight

545.54

Formula

C24H35NO13

Storage

Store at -20°C

Purity

≥90% (HPLC)

Chemical Name

(S)-1-((2R,3R,4S,6R)-3-Acetamido-4,6-diacetoxy-6-((pentyloxy)carbonyl)tetrahydro-2H-pyran-2-yl)-2-oxopropane-1,3-diyl diacetate

InChI Key

KHHBPFWAHJWVPW-PIIZRUITSA-N

SMILES

O=C([C@H]([C@@]1(O[C@@](C(OCCCCC)=O)(OC(C)=O)C[C@@H]([C@H]1NC(C)=O)OC(C)=O)[H])OC(C)=O)COC(C)=O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Solubility

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
DMSO 54.55 100
Ethanol 54.55 100

Preparing Stock Solutions for Ac4-8-keto-Neu5Ac n-pentyl ester

The following data is based on the product molecular weight 545.54.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.83 mL 9.17 mL 18.33 mL
5 mM 0.37 mL 1.83 mL 3.67 mL
10 mM 0.18 mL 0.92 mL 1.83 mL
50 mM 0.04 mL 0.18 mL 0.37 mL

Calculators

Calculate the mass, volume, or concentration required for a solution.

=
x
x
g/mol

*When preparing stock solutions always use the batch-specific molecular weight of the product found on the vial label and CoA (available online).

Calculate the dilution required to prepare a stock solution.

x
=
x

The reconstitution calculator allows you to quickly calculate the volume of a reagent to reconstitute your vial. Simply enter the mass of reagent and the target concentration and the calculator will determine the rest.

=
÷

Background References

References are publications that support the biological activity of the product.

Product Documents for Ac4-8-keto-Neu5Ac n-pentyl ester

Certificate of Analysis

To download a Certificate of Analysis, please enter a lot or batch number in the search box below.

Product Specific Notices for Ac4-8-keto-Neu5Ac n-pentyl ester

For research use only

Customer Reviews for Ac4-8-keto-Neu5Ac n-pentyl ester

There are currently no reviews for this product. Be the first to review Ac4-8-keto-Neu5Ac n-pentyl ester and earn rewards!

Have you used Ac4-8-keto-Neu5Ac n-pentyl ester?

Submit a review and receive an Amazon gift card!

$25/€18/£15/$25CAN/¥2500 for a review with an image

$10/€7/£6/$10CAN/¥1110 for a review without an image

Submit a review
Amazon Gift Card