GABA receptor agonist and modulator of glutamatergic systems. Reduces alcohol consumption in animal models of alcohol addiction.
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Acamprosate and alcohol: I. Effects on alcohol intake following alcohol deprivation in the rat.
Spanagel et al.
Acamprosate enhances N-methyl-D-aspartate receptor-mediated neurotransmission but inhibits presynaptic GABA(B) receptors in nucleus accumbens neurons.
Berton et al.
Alcohol Clin.Exp.Res., 1998;22:183
Interaction of acamprosate with ethanol and spermine on NMDA receptors in primary cultured neurons.
Popp and Lovinger