Catalog Number: 3618
Alternate Names: Calcium acetylhomotaurinate
Chemical Name: 3-(Acetylamino)-1-propanesulfonic acid hemicalcium salt
Biological Activity
GABA receptor agonist and modulator of glutamatergic systems. Reduces alcohol consumption in animal models of alcohol addiction.

Deuterated analog also available.

Technical Data
  • M.Wt:
    200.24
  • Formula:
    C5H10NO4S.½ Ca
  • Solubility:
    Soluble to 100 mM in water
  • Storage:
    Desiccate at RT
  • CAS No:
    77337-73-6
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis. All Tocris products are intended for laboratory research use only.
Additional Information
Other Product-Specific Information:
Background References
  1. Acamprosate and alcohol: I. Effects on alcohol intake following alcohol deprivation in the rat.
    Spanagel et al.
    Eur.J.Pharmacol., 1996;305:39
  2. Acamprosate enhances N-methyl-D-aspartate receptor-mediated neurotransmission but inhibits presynaptic GABA(B) receptors in nucleus accumbens neurons.
    Berton et al.
    Alcohol Clin.Exp.Res., 1998;22:183
  3. Interaction of acamprosate with ethanol and spermine on NMDA receptors in primary cultured neurons.
    Popp and Lovinger
    Eur.J.Pharmacol., 2000;394:221

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