High affinity angiotensin-converting enzyme (ACE) ligand (Kd
= 2.79 nM). Exhibits no significant effect on ACE enzymatic activity up to 500 nM concentration. Potentiates NMDA + D-serine-induced dopamine release from striatal slices in vitro
and the striatum in vivo
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The novel nonapeptide acein targets angiotensin converting enzyme in the brain and induces dopamine release.
Neasta et al.