Acein
Description: High affinity angiotensin-converting enzyme (ACE) ligand
Biological Activity
Acein is a high affinity angiotensin-converting enzyme (ACE) ligand (Kd = 2.79 nM). Exhibits no significant effect on ACE enzymatic activity up to 500 nM concentration. Potentiates NMDA + D-serine-induced dopamine release from striatal slices in vitro and the striatum in vivo.Technical Data
M.Wt:
932.5
Formula:
C43H68N10O13
Sequence:
PPTTTKFAA
Solubility:
Soluble to 2 mg/ml in water
Storage:
Store at -20°C
The technical data provided above is for guidance only.
For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Background References
-
The novel nonapeptide acein targets angiotensin converting enzyme in the brain and induces DA release.
Neasta et al.
Br.J.Pharmacol., 2016;173:1314
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