Catalog Number: 5852
Biological Activity
High affinity aspartic protease inhibitor. Inhibits HIV-1 protease (Ki = 20 nM at pH 4.7) and HIV-2 protease (Ki = 5 nM at pH 4.7). Antiviral.
Technical Data
  • M.Wt:
    643.81
  • Formula:
    C31H57N5O9
  • Sequence:
    VVA

    (Modifications: Val-1 = N-terminal Ac, Val-2 = Val-(3S,4S)-4-amino-3-hydroxy-6-methylheptanoyl, Ala-3 = Ala-(3S,4S)4-amino-3-hydroxy-6-methylheptanoic-acid)

  • Solubility:
    Soluble to 2 mg/ml in PBS
  • Storage:
    Store at -20°C
  • CAS No:
    11076-29-2
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis. All Tocris products are intended for laboratory research use only.
Background References
  1. Inhibition of XMRV and HIV-1 proteases by pepstatin A and acetyl-pepstatin.
    Mat?z et al.
    FEBS J., 2012;279:3276
  2. Effective blocking of HIV-1 proteinase activity by characteristic inhibitors of aspartic proteinases.
    Richards et al.
    FEBS Lett., 1989;247:113
  3. Inhibition of the aspartic proteinase from HIV-2.
    Richards et al.
    FEBS Lett., 1989;253:214

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