Acinus Antibody Blocking Peptide

Novus Biologicals | Catalog # NBP1-76855PEP

Novus Biologicals
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Key Product Details

Source

Synthetic

Applications

Antibody Competition
View all Acinus Proteins and Enzymes »

Product Specifications

Description

A blocking peptide containing 15 amino acids near the center of human Acinus.

Source: Synthetic

(Accession #: AAD56724)

Application Notes

This peptide is useful as a blocking peptide for NBP1-76855.

For further blocking peptide related protocol, click here.

Protein / Peptide Type

Antibody Blocking Peptide

Formulation, Preparation, and Storage

NBP1-76855PEP
Formulation PBS pH 7.2 (10 mM NaH2PO4, 10 mM Na2HPO4, 130 mM NaCl) containing 0.1% bovine serum albumin.
Preservative 0.02% Sodium Azide
Concentration 0.2 mg/ml
Shipping The product is shipped with polar packs. Upon receipt, store it immediately at the temperature recommended below.
Stability & Storage Store at -20C. Avoid freeze-thaw cycles.

Background: Acinus

Chromatin condensation and nuclear fragmentation (CCNF) are the hallmarks of apoptosis. CCNF is triggered by the activation of members of the caspase family, caspase activated DNase (CAD/DFF40), and several novel proteins including AIF and CIDE. A new inducer of chromatin condensation was recently identified and designated Acinus (for apoptotic chromatin condensation inducer in the nucleus). Acinus is cleaved by Caspase 3 and an additional unknown protease generating a small active peptide p17, which causes chromatin condensation in vitro when it is added to purified nuclei. Acinus also induces apoptotic chromatin condensation in cells. Acinus is ubiquitously expressed. Three different spliced forms of Acinus have been identified in human and mouse and designated Acinus L (1341 amino acids), Acinus S (583 amino acids) and Acinus S; (614 amino acids).

Alternate Names

Acinus, ACN, apoptotic chromatin condensation inducer 1, apoptotic chromatin condensation inducer in the nucleus, fSAP152, functional spliceosome-associated protein 152, KIAA0670DKFZp667N107

Gene Symbol

ACIN1

Additional Acinus Products

Product Documents for Acinus Antibody Blocking Peptide

Certificate of Analysis

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Product Specific Notices for Acinus Antibody Blocking Peptide

This product is for research use only and is not approved for use in humans or in clinical diagnosis. This product is guaranteed for 1 year from date of receipt.

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