Catalog Number: 1111
Chemical Name: (1S,3R,4S)-1-Aminocyclopentane-1,3,4-tricarboxylic acid
Biological Activity
Agonist for group III mGlu receptors (EC50 values are 7.2 and 8.2 μM for mGlu4a and mGlu8 respectively). Anticonvulsant in mice.
Technical Data
  • M.Wt:
  • Formula:
  • Solubility:
    Soluble to 10 mM in water and to 50 mM in 1.1eq. NaOH
  • Storage:
    Desiccate at -20°C
  • CAS No:
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis. All Tocris products are intended for laboratory research use only.
Additional Information
Licensing Caveats:
Sold with the permission of the CNRS
Background References
  1. Synthesis and pharmacological characterization of aminocyclopentanetricarboxylic acids: new tools to discriminate between metabotropic glutamate receptor subtypes.
    Acher et al.
    J.Med.Chem., 1997;40:3119
  2. Pharmacological characterization of the rat metabotropic glutamate receptor 8a revealed strong similarities and slight differences with the type 4a receptor.
    De Colle et al.
    Eur.J.Pharmacol., 2000;394:17
  3. Anticonvulsant activity of a mGlu receptor selective agonist, (1S,3R,4S)-1-aminocyclopentane-1,2,4-tricarboxylic acid.
    Chapman et al.
    Eur.J.Pharmacol., 2001;424:107

The citations listed below are publications that use Tocris products. Selected citations for ACPT-I include:

Showing Results 1 - 1 of 1

  1. Group III mGlu receptor agonist, ACPT-I, exerts potential neuroprotective effects in vitro and in vivo.
    Authors: Domin Et al.
    Proc Natl Acad Sci U S A
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