Key Product Details

Species Reactivity

Human, Mouse, Rat, Primate

Applications

Western Blot, Immunocytochemistry/ Immunofluorescence

Label

FITC (Excitation = 495 nm, Emission = 519 nm)

Antibody Source

Polyclonal Rabbit IgG
View all ACSL1 Primary Antibodies »

Product Specifications

Immunogen

Synthetic peptide made to an N-terminal portion of the human ACSL1 protein (within residues 1-100). [Swiss-Prot# P33121]

Localization

Single-pass type III membrane protein

Clonality

Polyclonal

Host

Rabbit

Isotype

IgG

Applications for ACSL1 Antibody [FITC]

Application
Recommended Usage

Immunocytochemistry/ Immunofluorescence

Optimal dilutions of this antibody should be experimentally determined.

Western Blot

Optimal dilutions of this antibody should be experimentally determined.
Application Notes
Optimal dilution of this antibody should be experimentally determined.

Formulation, Preparation, and Storage

Purification

Immunogen affinity purified

Formulation

PBS

Preservative

0.05% Sodium Azide

Concentration

Please see the vial label for concentration. If unlisted please contact technical services.

Shipping

The product is shipped with polar packs. Upon receipt, store it immediately at the temperature recommended below.

Stability & Storage

Store at 4C in the dark.

Background: ACSL1

ACSL1 (long-chain-fatty-acid--CoA ligase 1), belongs to ATP-dependent AMP-binding enzyme family and is one of the 5 isoforms (ACSL - 1, -3, -4, -5 and -6) of long chain acyl CoA synthetases (ACSLs), the enzymes which plays a crucial role in regulating fatty acid metabolism by converting free fatty acids (FFAs) into fatty acyl CoA derivatives via a process called fatty acid activation, a modification required for any FFA to undergo further metabolism. ACSL1 is a single-pass type III membrane protein localized in mitochondrion outer membrane and membranes of peroxisomes, microsomes, ER of energy-metabolizing tissues such as fat, liver, and skeletal muscles. ACSL1 is a central enzyme in the intermediary metabolism due to its fundamental role in activation of long-chain fatty acids through the incorporation of CoA. These bioactive fatty acid metabolites are involved in many cellular biochemical processes, including protein transport, enzyme activation, and transcriptional control. Additionally, fatty acyl-CoAs are used as substrates in fatty acid beta-oxidation and the phospholipid biosynthesis pathways.

Alternate Names

ACS1LACS 2, Acyl-CoA synthetase 1, acyl-CoA synthetase long-chain family member 1, EC 6.2.1, FACL1EC 6.2.1.3, fatty-acid-Coenzyme A ligase, long-chain 1, LACS 1, LACSlong-chain 2, lignoceroyl-CoA synthase, Long-chain acyl-CoA synthetase 1, Long-chain acyl-CoA synthetase 2, Long-chain fatty acid-CoA ligase 2, long-chain fatty-acid-coenzyme A ligase 1, long-chain-fatty-acid--CoA ligase 1, Palmitoyl-CoA ligase 1, Palmitoyl-CoA ligase 2, paltimoyl-CoA ligase 1

Gene Symbol

ACSL1

Additional ACSL1 Products

Product Documents for ACSL1 Antibody [FITC]

Certificate of Analysis

To download a Certificate of Analysis, please enter a lot or batch number in the search box below.

Download SDS

Product Specific Notices for ACSL1 Antibody [FITC]

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

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Protocols

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FAQs

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