Potent and selective orexin OX1
receptor antagonist (Kb
values are 41 and 560 nM for OX1
receptors respectively). Elicits anxiolytic effects in vivo
. Brain penetrant and orally available.
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
Discovery and characterization of ACT-335827, an orally available, brain penetrant orexin receptor type 1 selective antagonist.
Steiner et al.