Acyclovir

Catalog # Availability Size / Price Qty
2513/50
Acyclovir | CAS No. 59277-89-3 | RNA/DNA Polymerase Inhibitors
1 Image
Description: Inhibits viral DNA polymerase; antiherpetic agent
Alternative Names: Aciclovir, Acycloguanosine

Chemical Name: 2-Amino-1,9-dihydro-9-[(2-hydroxyethoxy)methyl]-6H-purin-6-one

Purity: ≥99%

Product Details
Reviews (1)

Biological Activity

Antiviral agent, active against herpes simplex viruses HSV-1 and HSV-2 (EC50 values are 0.85 and 0.86 μM respectively). Interferes with viral DNA polymerization through competitive inhibition with guanosine triphosphate. Induces apoptosis in cells transfected with HSV-TK (suicidal gene therapy).

Technical Data

M.Wt:
225.21
Formula:
C8H11N5O3
Solubility:
Soluble to 50 mM in 1eq. HCl and to 20 mM in DMSO
Purity:
≥99%
Storage:
Store at RT
CAS No:
59277-89-3

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.

Background References

  1. The role of a HSV thymidine kinase stimulating substance, scopadulciol, in improving the efficacy of cancer gene therapy.
    Hayashi et al.
    J.Gene.Med., 2006;8:1056
  2. Synergistic antiviral activity of acyclovir and vidarabine against herpes simplex virus types 1 and 2 and varicella-zoster virus.
    Suzuki et al.
    Antiviral Res., 2006;72:157
  3. Selectivity of action of an antiherpetic agent, 9-(2-hydroxyethoxymethyl)guanine.
    Elion et al.
    Proc.Natl.Acad.Sci.USA., 1977;74:5716

Product Datasheets

or select another batch:
Reconstitution Calculator
Molarity Calculator

Reconstitution Calculator

The reconstitution calculator allows you to quickly calculate the volume of a reagent to reconstitute your vial. Simply enter the mass of reagent and the target concentration and the calculator will determine the rest.

=
÷

Molarity Calculator

=
x
x
g/mol

*When preparing stock solutions always use the batch-specific molecular weight of the product found on the vial label and SDS / CoA (available online).

FAQs

No product specific FAQs exist for this product, however you may

View all Small Molecule FAQs

Reviews for Acyclovir

Average Rating: 4 (Based on 1 Review)

5 Star
0%
4 Star
100%
3 Star
0%
2 Star
0%
1 Star
0%

Have you used Acyclovir?

Submit a review and receive an Amazon gift card.

$25/€18/£15/$25CAN/¥75 Yuan/¥1250 Yen for a review with an image

$10/€7/£6/$10 CAD/¥70 Yuan/¥1110 Yen for a review without an image

Submit a Review

Filter by:


Acyclovir was studied in conjunction with few contemporary chemotherapy strategies
By Anonymous on 08/18/2019
Species: Human

Acyclovir's effect was seen to increased when used with certain other medicines namely chemotherapeutic. Acyclovir was studied in conjunction with few contemporary chemotherapy strategies.


Tocris Bioscience is the leading supplier of novel and exclusive tools for life science research with over 30 years' experience in the industry. Tocris is a Bio-Techne brand.