Catalog Number: 2513
Alternate Names: Aciclovir, Acycloguanosine
Chemical Name: 2-Amino-1,9-dihydro-9-[(2-hydroxyethoxy)methyl]-6H-purin-6-one
Biological Activity
Antiviral agent, active against herpes simplex viruses HSV-1 and HSV-2 (EC50 values are 0.85 and 0.86 μM respectively). Interferes with viral DNA polymerization through competitive inhibition with guanosine triphosphate. Induces apoptosis in cells transfected with HSV-TK (suicidal gene therapy).
Technical Data
  • M.Wt:
    225.21
  • Formula:
    C8H11N5O3
  • Solubility:
    Soluble to 50 mM in 1eq. HCl and to 20 mM in DMSO
  • Purity:
    >99%
  • Storage:
    Store at RT
  • CAS No:
    59277-89-3
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis. All Tocris products are intended for laboratory research use only.
Background References
  1. The role of a HSV thymidine kinase stimulating substance, scopadulciol, in improving the efficacy of cancer gene therapy.
    Hayashi et al.
    J.Gene.Med., 2006;8:1056
  2. Synergistic antiviral activity of acyclovir and vidarabine against herpes simplex virus types 1 and 2 and varicella-zoster virus.
    Suzuki et al.
    Antiviral Res., 2006;72:157
  3. Selectivity of action of an antiherpetic agent, 9-(2-hydroxyethoxymethyl)guanine.
    Elion et al.
    Proc.Natl.Acad.Sci.USA., 1977;74:5716

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