Antiviral agent, active against herpes simplex viruses HSV-1 and HSV-2 (EC50
values are 0.85 and 0.86 μ
M respectively). Interferes with viral DNA polymerization through competitive inhibition with guanosine triphosphate. Induces apoptosis in cells transfected with HSV-TK (suicidal gene therapy).
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The role of a HSV thymidine kinase stimulating substance, scopadulciol, in improving the efficacy of cancer gene therapy.
Hayashi et al.
Synergistic antiviral activity of acyclovir and vidarabine against herpes simplex virus types 1 and 2 and varicella-zoster virus.
Suzuki et al.
Antiviral Res., 2006;72:157
Selectivity of action of an antiherpetic agent, 9-(2-hydroxyethoxymethyl)guanine.
Elion et al.