Chemical Name: 6-Aminopurine hydrochloride
Biological ActivityHigh affinity adenine receptor agonist (Ki = 18 nM at rat adenine receptor). Inhibits forskolin-stimulated cAMP formation in CHO cells transfected with the adenine receptor; also stimulates GTPγS binding (pEC50 values are 8.54 and 7.21 respectively).
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Tocris products are intended for laboratory research use only, unless stated otherwise.
Evidence for the functional expression and pharmacological characterization of adenine receptors in native cells and tissues.
Gorzalka et al.
Characterization of an orphan G protein-coupled receptor localized in the dorsal root ganglia reveals adenine as a signaling molecule.
Bender et al.
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