High affinity adenine receptor agonist (Ki
= 18 nM at rat adenine receptor). Inhibits forskolin-stimulated cAMP formation in CHO cells transfected with the adenine receptor; also stimulates GTPγ
S binding (pEC50
values are 8.54 and 7.21 respectively).
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Evidence for the functional expression and pharmacological characterization of adenine receptors in native cells and tissues.
Gorzalka et al.
Characterization of an orphan G protein-coupled receptor localized in the dorsal root ganglia reveals adenine as a signaling molecule.
Bender et al.