Catalog Number: 4202
Chemical Name: 6-Aminopurine hydrochloride
Biological Activity
High affinity adenine receptor agonist (Ki = 18 nM at rat adenine receptor). Inhibits forskolin-stimulated cAMP formation in CHO cells transfected with the adenine receptor; also stimulates GTPγS binding (pEC50 values are 8.54 and 7.21 respectively).
Technical Data
  • M.Wt:
    171.59
  • Formula:
    C5H5N5.HCl
  • Solubility:
    Soluble to 100 mM in water and to 100 mM in DMSO
  • Purity:
    >99%
  • Storage:
    Desiccate at RT
  • CAS No:
    6055-72-7
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis. All Tocris products are intended for laboratory research use only.
Background References
  1. Evidence for the functional expression and pharmacological characterization of adenine receptors in native cells and tissues.
    Gorzalka et al.
    Mol.Pharmacol., 2005;67:955
  2. Characterization of an orphan G protein-coupled receptor localized in the dorsal root ganglia reveals adenine as a signaling molecule.
    Bender et al.
    Proc.Natl.Acad.Sci., 2002;99:8573

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