Agonist of adiponectin receptors AdipoR1 and AdipoR2 (Kd
values are 1.8 and 3.1 μ
M respectively). Activates AMPK and PPARα
signaling; ameliorates insulin resistance, dyslipidemia and glucose intolerance in db/db
mice. Orally active antidiabetic agent.
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A small-molecule AdipoR agonist for type 2 diabetes and short life in obesity.
Okada-Iwabu et al.