ADU-S100 disodium salt

Key Product Details

Product Description

ADU-S100 disodium salt is a STING agonist. It induces CD8+ T-cell mediated antitumor immunity in a rat esophageal adenocarcinoma model. In mouse tumor models, the compound induces tumor regression and a potent antitumor immune response. ADU-S100 disodium salt induces phosphorylation of TBK1 and IRF3 in murine bone marrow macrophages.

Product Specifications for ADU-S100 disodium salt

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Solubility

Preparing Stock Solutions for ADU-S100 disodium salt

The following data is based on the product molecular weight 734.50.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:

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Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
0.05 mM	27.23 mL	136.15 mL	272.29 mL
0.25 mM	5.45 mL	27.23 mL	54.46 mL
0.5 mM	2.72 mL	13.61 mL	27.23 mL
2.5 mM	0.54 mL	2.72 mL	5.45 mL

Calculators

Background References

References are publications that support the biological activity of the product.

• Zaidi Intratumoral immunotherapy with STING agonist, ADU-S100, induces CD8+ T-cell mediated anti-tumor immunity in an esophageal adenocarcinoma model. Oncotarget 2021 PMID: 33659041
• Corrales Direct activation of STING in the tumor microenvironment leads to potent and systemic tumor regression and immunity. Cell Rep. 2015 PMID: 25959818

Product Documents for ADU-S100 disodium salt