Broad spectrum, irreversible inhibitor of serine proteases. Also inhibits NADPH oxidase activation in vitro
. Attenuates airway inflammation in a mouse model of airway allergy.
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Inhibition of NADPH oxidase activation by 4-(2-aminoethyl)-benzenesulfonyl fluoride and related compounds.
Diatchuk et al.
Serine protease inhibitor attenuates ovalbumin induced inflammation in mouse model of allergic airway disease.
Saw et al.
PLoS ONE, 2012;7:e41107