Chemical Name: 6-Phenylimidazo[2,1-b]-1,3,4-thiadiazole-2-sulfonamide
Biological Activity Inhibitor of c-jun N-terminal kinase (JNK) signaling. Binds Hsp90 and facilitates HSF1 release, induces expression of Hsp70, which in turn blocks JNK activation and JNK-dependent apoptosis. Antiapoptotic; inhibits NGF withdrawal-induced death in SCG neurons (EC50 = 20 μM).
Soluble to 100 mM in DMSO and to 5 mM in ethanol
Store at RT
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