AEG 3482

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2651/10
2651/50
AEG 3482 | CAS No. 63735-71-7 | JNK/c-jun Inhibitors
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Description: Inhibitor of JNK signaling

Chemical Name: 6-Phenylimidazo[2,1-b]-1,3,4-thiadiazole-2-sulfonamide

Purity: ≥99%

Product Details
Citations (5)
Reviews (1)

Biological Activity

Inhibitor of c-jun N-terminal kinase (JNK) signaling. Binds Hsp90 and facilitates HSF1 release, induces expression of Hsp70, which in turn blocks JNK activation and JNK-dependent apoptosis. Antiapoptotic; inhibits NGF withdrawal-induced death in SCG neurons (EC50 = 20 μM).

Technical Data

M.Wt:
280.33
Formula:
C10H8N4O2S2
Solubility:
Soluble to 100 mM in DMSO and to 5 mM in ethanol
Purity:
≥99%
Storage:
Store at RT
CAS No:
63735-71-7

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.

Product Datasheets

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Citations for AEG 3482

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5 Citations: Showing 1 - 5

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42 perturbagens used the zebrafish DASPEI screen
By Anonymous on 12/17/2019
Species: Other

Zebrafish larvae were placed into 48-well plates and used the DASPEI screen by 42 perturbagens drugs, including this compound

PMID: 30532693

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