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AEG 3482

Catalog #: 2651
5 Citations Datasheet / COA / SDS
Catalog # Availability Size / Price Qty
2651/10
2651/50
AEG 3482 | CAS No. 63735-71-7 | JNK/c-jun Inhibitors
1 Image
Description: Inhibitor of JNK signaling

Chemical Name: 6-Phenylimidazo[2,1-b]-1,3,4-thiadiazole-2-sulfonamide

Purity: ≥99%

Product Details
Citations (5)
Reviews
Biological Activity Technical Data Background Product Datasheets Calculators

Biological Activity

AEG 3482 is an inhibitor of c-jun N-terminal kinase (JNK) signaling. Binds Hsp90 and facilitates HSF1 release, induces expression of Hsp70, which in turn blocks JNK activation and JNK-dependent apoptosis. Antiapoptotic; inhibits NGF withdrawal-induced death in SCG neurons (EC50 = 20 μM).

Technical Data

M.Wt:
280.33
Formula:
C10H8N4O2S2
Solubility:
Soluble to 100 mM in DMSO and to 5 mM in ethanol
Purity:
≥99%
Storage:
Store at RT
CAS No:
63735-71-7

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.

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Product Datasheets

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Citations for AEG 3482

The citations listed below are publications that use Tocris products. Selected citations for AEG 3482 include:

5 Citations: Showing 1 - 5

  1. Targeting JNK pathway promotes human hematopoietic stem cell expansion.
    Authors: Xiao Et al.
    Cell Discov  2019;5:2
  2. The Inner Ear Heat Shock Transcriptional Signature Identifies Compounds That Protect Against Aminoglycoside Ototoxicity.
    Authors: Ryals Et al.
    Front Cell Neurosci  2018;12:445
  3. Syndecan-1 Acts as an Important Regulator of CXCL1 Expression and Cellular Interaction of Human Endometrial Stromal and Trophoblast Cells.
    Authors: Baston-Buest Et al.
    Mediators Inflamm  2017;2017:8379256
  4. ERK2 phosphorylates Krüppel-like factor 8 protein at serine 48 to maintain its stability.
    Authors: Lahiri Et al.
    Am J Cancer Res  2016;6:910
  5. CDK5 is essential for soluble amyloid β-induced degradation of GKAP and remodeling of the synaptic actin cytoskeleton.
    Authors: Roselli Et al.
    PLoS One  2011;6:e23097

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