Catalog Number: 2651
Chemical Name: 6-Phenylimidazo[2,1-b]-1,3,4-thiadiazole-2-sulfonamide
Biological Activity
Inhibitor of c-jun N-terminal kinase (JNK) signaling. Binds Hsp90 and facilitates HSF1 release, induces expression of Hsp70, which in turn blocks JNK activation and JNK-dependent apoptosis. Antiapoptotic; inhibits NGF withdrawal-induced death in SCG neurons (EC50 = 20 μM).
Technical Data
  • M.Wt:
    280.33
  • Formula:
    C10H8N4O2S2
  • Solubility:
    Soluble to 100 mM in DMSO and to 5 mM in ethanol
  • Purity:
    >99%
  • Storage:
    Store at RT
  • CAS No:
    63735-71-7
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis. All Tocris products are intended for laboratory research use only.
Background References
  1. Targeting HSP90 to halt neurodegeneration.
    Gallo
    Chem.Biol., 2006;13:115
  2. AEG3482 is an antiapoptotic compound that inhibits Jun kinase activity and cell death through induced expression of heat shock protein 70.
    Salehi et al.
    Chem.Biol., 2006;13:213

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