Chemical Name: 6-Phenylimidazo[2,1-b]-1,3,4-thiadiazole-2-sulfonamide
Biological ActivityAEG 3482 is an inhibitor of c-jun N-terminal kinase (JNK) signaling. Binds Hsp90 and facilitates HSF1 release, induces expression of Hsp70, which in turn blocks JNK activation and JNK-dependent apoptosis. Antiapoptotic; inhibits NGF withdrawal-induced death in SCG neurons (EC50 = 20 μM).
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Targeting HSP90 to halt neurodegeneration.
AEG3482 is an antiapoptotic compound that inhibits Jun kinase activity and cell death through induced expression of heat shock protein 70.
Salehi et al.
Citations for AEG 3482
The citations listed below are publications that use Tocris products. Selected citations for AEG 3482 include:
5 Citations: Showing 1 - 5
Targeting JNK pathway promotes human hematopoietic stem cell expansion.
Authors: Xiao Et al.
Cell Discov 2019;5:2
The Inner Ear Heat Shock Transcriptional Signature Identifies Compounds That Protect Against Aminoglycoside Ototoxicity.
Authors: Ryals Et al.
Front Cell Neurosci 2018;12:445
Syndecan-1 Acts as an Important Regulator of CXCL1 Expression and Cellular Interaction of Human Endometrial Stromal and Trophoblast Cells.
Authors: Baston-Buest Et al.
Mediators Inflamm 2017;2017:8379256
ERK2 phosphorylates Krüppel-like factor 8 protein at serine 48 to maintain its stability.
Authors: Lahiri Et al.
Am J Cancer Res 2016;6:910
CDK5 is essential for soluble amyloid β-induced degradation of GKAP and remodeling of the synaptic actin cytoskeleton.
Authors: Roselli Et al.
PLoS One 2011;6:e23097
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Zebrafish larvae were placed into 48-well plates and used the DASPEI screen by 42 perturbagens drugs, including this compound