AEG 3482

  ( 2 citations )    
Product Datasheet
Catalog Number:2651
Chemical Name:6-Phenylimidazo[2,1-b]-1,3,4-thiadiazole-2-sulfonamide
Product Details
Citations (2)
Reviews
Biological Activity
Inhibitor of c-jun N-terminal kinase (JNK) signaling. Binds Hsp90 and facilitates HSF1 release, induces expression of Hsp70, which in turn blocks JNK activation and JNK-dependent apoptosis. Antiapoptotic; inhibits NGF withdrawal-induced death in SCG neurons (EC50 = 20 μM).
Technical Data
  • M.Wt:
    280.33
  • Formula:
    C10H8N4O2S2
  • Solubility:
    Soluble to 100 mM in DMSO and to 5 mM in ethanol
  • Purity:
    >99
  • Storage:
    Store at RT
  • CAS No:
    63735-71-7
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis. All Tocris products are intended for laboratory research use only.
Product Datasheets
Citations:

The citations listed below are publications that use Tocris products. Selected citations for AEG 3482 include:

2 Citations: Showing 1 - 2
Filter your results:

  1. ERK2 phosphorylates Krüppel-like factor 8 protein at serine 48 to maintain its stability.
    Authors: Lahiri Et al.
    Am J Cancer Res  2016;6:910
  2. CDK5 is essential for soluble amyloid β-induced degradation of GKAP and remodeling of the synaptic actin cytoskeleton.
    Authors: Roselli Et al.
    PLoS One  2011;6:e23097

FAQs

No product specific FAQs exist for this product, however you may

View all Small Molecule FAQs

Have you used AEG 3482?

Submit a review and receive a $25US/€18/£15/$25CAN amazon gift card if you include an image - $10US/€7/£6/$10CAN Amazon card for reviews without an image. Limited to verified customers in USA, Canada and Europe.

Tocris Bioscience is the leading supplier of novel and exclusive tools for life science research with over 30 years' experience in the industry. Tocris is a Bio-Techne brand.

Order Details

Contact Us to Order
reload

Feedback

Customer Information
Calculators

Molarity Calculator

Calculate the mass, volume, or concentration required for a solution.
=
x
x
g/mol

*When preparing stock solutions always use the batch-specific molecular weight of the product found on the vial label and SDS / CoA (available online).

R&D Systems Guarantee