AEG 3482

Catalog # Availability Size / Price Qty
2651/10
2651/50
AEG 3482 | CAS No. 63735-71-7 | JNK/c-jun Inhibitors
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Description: Inhibitor of JNK signaling

Chemical Name: 6-Phenylimidazo[2,1-b]-1,3,4-thiadiazole-2-sulfonamide

Purity: ≥99%

Product Details
Citations (5)
Reviews

Biological Activity

AEG 3482 is an inhibitor of c-jun N-terminal kinase (JNK) signaling. Binds Hsp90 and facilitates HSF1 release, induces expression of Hsp70, which in turn blocks JNK activation and JNK-dependent apoptosis. Antiapoptotic; inhibits NGF withdrawal-induced death in SCG neurons (EC50 = 20 μM).

Technical Data

M.Wt:
280.33
Formula:
C10H8N4O2S2
Solubility:
Soluble to 100 mM in DMSO and to 5 mM in ethanol
Purity:
≥99%
Storage:
Store at RT
CAS No:
63735-71-7

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.

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Citations for AEG 3482

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5 Citations: Showing 1 - 5

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