Chemical Name: N-[[4-Chloro-2-(1-methylethoxy)phenyl]methyl]-5-phenyl-[1,2,4]triazolo[1,5-a]pyrimidin-7-amine
Biological ActivityPotent and selective GPR3 inverse agonist (pIC50 = 7.3). Selective for GPR3 over GPR6 and GPR12 (pIC50 values are 5.1 and 4.9, respectively).
The technical data provided above is for guidance only.
For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
The identification of GPR3 inverse agonist AF64394; the first small molecule inhibitor of GPR3 receptor function.
Jensen et al.
Mice lacking GPR3 receptors display late-onset obese phenotype due to impaired thermogenic function in brown adipose tissue.
Godlewski et al.
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