AF-DX 116

Key Product Details

Product Description

AF-DX 116 is a selective M₂ muscarinic receptor antagonist. K_i values are 64, 417, 786, 211 and 5130 nM for human recombinant M₂, M₁, M₃, M₄ and M₅ muscarinic receptors, respectively.

Licensing Information

Sold with the permission of Boehringer Ingelheim GmbH

Product Specifications for AF-DX 116

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Solubility

Preparing Stock Solutions for AF-DX 116

The following data is based on the product molecular weight 421.54.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:

4 3 2 1 Recalculate

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
0.25 mM	9.49 mL	47.45 mL	94.89 mL
1.25 mM	1.90 mL	9.49 mL	18.98 mL
2.5 mM	0.95 mL	4.74 mL	9.49 mL
12.5 mM	0.19 mL	0.95 mL	1.90 mL

Calculators

Background References

References are publications that support the biological activity of the product. See our Citations tab to view 70 publications citing the usage of this product.

• Mansfield Muscarinic receptor subtypes in human bladder detrusor and mucosa, studied by radioligand binding and quantitative competitive RT-PCR: changes in ageing. Br.J.Pharmacol. 2005 PMID: 15723094
• Eglen Muscarinic receptor subtypes and smooth muscle function. Pharmacol.Rev. 1996 PMID: 8981565
• Hammer Binding profile of a novel cardioselective muscarinic receptor antagonist, AF-DX 116, to membranes of peripheral tissues and brain in the rat. Life Sci. 1986 PMID: 3754610
• Billard Identification of the primary muscarinic autoreceptor subtype in rat striatum as M₂ through a correlation of in vivo microdialysis and in vitro receptor binding data. J.Pharmacol.Exp.Ther. 1995 PMID: 7714776

Product Documents for AF-DX 116