AF-DX 116

Catalog # Availability Size / Price Qty
1105/10
1105/50
AF-DX 116 | CAS No. 102394-31-0 | mAChR M2 Antagonists
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Description: Selective M2 antagonist
Alternative Names: Otenzepad

Chemical Name: 11-[[2-[(Diethylamino)methyl]-1-piperidinyl]acetyl]-5,11-dihydro-6H-pyrido[2,3-b][1,4]benzodiazepin-6-one

Purity: ≥98%

Product Details
Citations (9)
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Reviews

Biological Activity

Selective M2 muscarinic receptor antagonist. Ki values are 64, 417, 786, 211 and 5130 nM for human recombinant M2, M1, M3, M4 and M5 muscarinic receptors, respectively.

Technical Data

M.Wt:
421.54
Formula:
C24H31N5O2
Solubility:
Soluble to 25 mM in DMSO with gentle warming
Purity:
≥98%
Storage:
Store at RT
CAS No:
102394-31-0

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.

Additional Information

Licensing Caveats:
Sold with the permission of Boehringer Ingelheim GmbH

Product Datasheets

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Citations for AF-DX 116

The citations listed below are publications that use Tocris products. Selected citations for AF-DX 116 include:

9 Citations: Showing 1 - 9

  1. Olfactory Bulb Muscarinic Acetylcholine Type 1 Receptors Are Required for Acquisition of Olfactory Fear Learning.
    Authors: Ross Et al.
    Front Behav Neurosci  2019;13:164
  2. Ion Fluxes through KCa2 (SK) and Cav1 (L-type) Channels Contribute to Chronoselectivity of Adenosine A1 Receptor-Mediated Actions in Spontaneously Beating Rat Atria.
    Authors: Bragança Et al.
    Front Pharmacol  2016;7:45
  3. Acetylcholine release in mouse hippocampal CA1 preferentially activates inhibitory-selective interneurons via α4β2* nicotinic receptor activation.
    Authors: Bell Et al.
    J Neurosci  2015;9:115
  4. M2 Muscarinic acetylcholine receptor modulates rat airway smooth muscle cell proliferation.
    Authors: Placeres-Uray Et al.
    World Allergy Organ J  2014;6:22
  5. Distinct muscarinic acetylcholine receptor subtypes mediate pre- and postsynaptic effects in rat neocortex.
    Authors: Gigout Et al.
    BMC Neurosci  2012;13:42
  6. M3 muscarinic receptors mediate positive inotropic responses in mouse atria: a study with muscarinic receptor knockout mice.
    Authors: Kitazawa Et al.
    Front Cell Neurosci  2009;330:487
  7. Cholinergic innervation of the guinea-pig isolated vas deferens.
    Authors: Solanki Et al.
    Naunyn Schmiedebergs Arch Pharmacol  2007;376:265
  8. Coregulation of natively expressed pertussis toxin-sensitive muscarinic receptors with G-protein-activated potassium channels.
    Authors: Clancy Et al.
    Proc Natl Acad Sci U S A  2007;27:6388
  9. Involvement of nitric oxide in depolarization-induced suppression of inhibition in hippocampal pyramidal cells during activation of cholinergic receptors.
    Authors: Makara Et al.
    J Neurosci  2007;27:10211

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