Catalog Number: 1105
Alternate Names: Otenzepad
Chemical Name: 11-[[2-[(Diethylamino)methyl]-1-piperidinyl]acetyl]-5,11-dihydro-6H-pyrido[2,3-b][1,4]benzodiazepin-6-one
Biological Activity
Selective M2 muscarinic receptor antagonist. Ki values are 64, 417, 786, 211 and 5130 nM for human recombinant M2, M1, M3, M4 and M5 muscarinic receptors, respectively.
Technical Data
  • M.Wt:
    421.54
  • Formula:
    C24H31N5O2
  • Solubility:
    Soluble to 25 mM in DMSO with gentle warming
  • Purity:
    >98%
  • Storage:
    Store at RT
  • CAS No:
    102394-31-0
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis. All Tocris products are intended for laboratory research use only.
Additional Information
Licensing Caveats:
Sold with the permission of Boehringer Ingelheim GmbH
Background References
  1. Identification of the primary muscarinic autoreceptor subtype in rat striatum as M2 through a correlation of in vivo microdialysis and in vitro receptor binding data.
    Billard et al.
    J.Pharmacol.Exp.Ther., 1995;273:273
  2. Muscarinic receptor subtypes and smooth muscle function.
    Eglen et al.
    Pharmacol.Rev., 1996;48:531
  3. Muscarinic receptor subtypes in human bladder detrusor and mucosa, studied by radioligand binding and quantitative competitive RT-PCR: changes in ageing.
    Mansfield et al.
    Br.J.Pharmacol., 2005;114:1089
  4. Binding profile of a novel cardioselective muscarinic receptor antagonist, AF-DX 116, to membranes of peripheral tissues and brain in the rat.
    Hammer et al.
    Life Sci., 1986;38:1653
Citations:

The citations listed below are publications that use Tocris products. Selected citations for AF-DX 116 include:

4 Citations: Showing 1 - 4
Filter your results:

  1. Acetylcholine release in mouse hippocampal CA1 preferentially activates inhibitory-selective interneurons via α4β2* nicotinic receptor activation.
    Authors: Bell Et al.
    J Neurosci 2015;9:115
  2. M2 Muscarinic acetylcholine receptor modulates rat airway smooth muscle cell proliferation.
    Authors: Placeres-Uray Et al.
    World Allergy Organ J 2014;6:22
  3. M3 muscarinic receptors mediate positive inotropic responses in mouse atria: a study with muscarinic receptor knockout mice.
    Authors: Kitazawa Et al.
    Front Cell Neurosci 2009;330:487
  4. Coregulation of natively expressed pertussis toxin-sensitive muscarinic receptors with G-protein-activated potassium channels.
    Authors: Clancy Et al.
    Proc Natl Acad Sci U S A 2007;27:6388

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