Catalog Number: 1345
Chemical Name: N-[2-[2-[(Dipropylamino)methyl]-1-piperidinyl]ethyl]-5,6-dihydro-6-oxo-11H-pyrido[2,3-b][1,4]benzodiazepine-11-carboxamide
Biological Activity
Potent M2/M4 selective antagonist (pKi values are 8.22, 8.00, 7.51, 7.18 and 6.27 at human M2, M4, M1, M3 and M5 receptors respectively).
Technical Data
  • M.Wt:
    478.64
  • Formula:
    C27H38N6O2
  • Solubility:
    Soluble to 50 mM in DMSO and to 10 mM in ethanol
  • Purity:
    >98%
  • Storage:
    Store at RT
  • CAS No:
    118290-26-9
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis. All Tocris products are intended for laboratory research use only.
Background References
  1. AF-DX 384 binding in rabbit cingulate cortex: two site kinetics and section autoradiography.
    Dopke et al.
    J.Pharmacol.Exp.Ther., 1995;274:562
  2. Regional changes in the cholinergic system in mice lacking monoamine A.
    Grailhe et al.
    Brain Res.Bull., 2009;78:283
  3. Binding of [3H]AF-DX 384 to cloned and native muscarinic receptors.
    Miller et al.
    J.Pharmacol.Exp.Ther., 1991;259:601

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