Chemical Name: N-[2-[2-[(Dipropylamino)methyl]-1-piperidinyl]ethyl]-5,6-dihydro-6-oxo-11H-pyrido[2,3-b][1,4]benzodiazepine-11-carboxamide
Biological ActivityAF-DX 384 is a potent M2/M4 selective antagonist (pKi values are 8.22, 8.00, 7.51, 7.18 and 6.27 at human M2, M4, M1, M3 and M5 receptors respectively).
The technical data provided above is for guidance only.
For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
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Regional changes in the cholinergic system in mice lacking monoamine A.
Grailhe et al.
Brain Res.Bull., 2009;78:283
AF-DX 384 binding in rabbit cingulate cortex: two site kinetics and section autoradiography.
Dopke et al.
Binding of [3H]AF-DX 384 to cloned and native muscarinic receptors.
Miller et al.
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