AF-DX 384

Tocris Bioscience | Catalog # 1345

Potent M2/M4 antagonist
Tocris Bioscience

Key Product Details

Description

Potent M2/M4 antagonist
View all mAChR M2 Antagonists »

Product Description

AF-DX 384 is a potent M2/M4 selective antagonist (pKi values are 8.22, 8.00, 7.51, 7.18 and 6.27 at human M2, M4, M1, M3 and M5 receptors respectively).

Product Specifications for AF-DX 384

Molecular Weight

478.64

Formula

C27H38N6O2

Storage

Store at RT

Purity

≥98% (HPLC)

Chemical Name

N-[2-[2-[(Dipropylamino)methyl]-1-piperidinyl]ethyl]-5,6-dihydro-6-oxo-11H-pyrido[2,3-b][1,4]benzodiazepine-11-carboxamide

CAS Number

118290-26-9

PubChem ID

119357

InChI Key

MZDYABXXPZNUCT-UHFFFAOYSA-N

SMILES

CCCN(CCC)CC1CCCCN1CCNC(=O)N1C2=C(C=CC=C2)C(=O)NC2=C1N=CC=C2

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Solubility

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
DMSO 23.93 50
Ethanol 4.79 10

Preparing Stock Solutions for AF-DX 384

The following data is based on the product molecular weight 478.64.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.5 mM 4.18 mL 20.89 mL 41.79 mL
2.5 mM 0.84 mL 4.18 mL 8.36 mL
5 mM 0.42 mL 2.09 mL 4.18 mL
25 mM 0.08 mL 0.42 mL 0.84 mL

Calculators

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Background References

References are publications that support the biological activity of the product. See our Citations tab to view 8 publications citing the usage of this product.

Product Documents for AF-DX 384

Certificate of Analysis

To download a Certificate of Analysis, please enter a lot or batch number in the search box below.

Product Specific Notices for AF-DX 384

For research use only

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