AF-DX 384

Catalog # Availability Size / Price Qty
1345/10
1345/50
AF-DX 384 | CAS No. 118290-26-9 | mAChR M2 Antagonists
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Description: Potent M2/M4 antagonist

Chemical Name: N-[2-[2-[(Dipropylamino)methyl]-1-piperidinyl]ethyl]-5,6-dihydro-6-oxo-11H-pyrido[2,3-b][1,4]benzodiazepine-11-carboxamide

Purity: ≥98%

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Biological Activity

AF-DX 384 is a potent M2/M4 selective antagonist (pKi values are 8.22, 8.00, 7.51, 7.18 and 6.27 at human M2, M4, M1, M3 and M5 receptors respectively).

Technical Data

M.Wt:
478.64
Formula:
C27H38N6O2
Solubility:
Soluble to 50 mM in DMSO and to 10 mM in ethanol
Purity:
≥98%
Storage:
Store at RT
CAS No:
118290-26-9

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.

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Background References

  1. Regional changes in the cholinergic system in mice lacking monoamine A.
    Grailhe et al.
    Brain Res.Bull., 2009;78:283
  2. AF-DX 384 binding in rabbit cingulate cortex: two site kinetics and section autoradiography.
    Dopke et al.
    J.Pharmacol.Exp.Ther., 1995;274:562
  3. Binding of [3H]AF-DX 384 to cloned and native muscarinic receptors.
    Miller et al.
    J.Pharmacol.Exp.Ther., 1991;259:601

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