Key Product Details

Species Reactivity

Validated:

Human

Cited:

Human

Predicted:

Bovine (94%). Backed by our 100% Guarantee.

Applications

Validated:

Immunohistochemistry, Immunohistochemistry-Paraffin, Western Blot

Cited:

Western Blot, IF/IHC

Label

Unconjugated

Antibody Source

Polyclonal Rabbit IgG

Format

BSA Free
View all AG-2/AGR2 Primary Antibodies »

Product Specifications

Immunogen

A synthetic peptide corresponding to an internal region of human AGR2 (within residues 50-100). [UniProt# O95994]

Reactivity Notes

Immunogen displays the following percentage of sequence identity for non-tested species: bovine (94%) and mouse (88%).

Localization

Secreted

Clonality

Polyclonal

Host

Rabbit

Isotype

IgG

Description

Novus Biologicals Rabbit AG-2/AGR2 Antibody - BSA Free (NB110-17780) is a polyclonal antibody validated for use in IHC and WB. Anti-AG-2/AGR2 Antibody: Cited in 7 publications. All Novus Biologicals antibodies are covered by our 100% guarantee.

Scientific Data Images for AG-2/AGR2 Antibody - BSA Free

Immunohistochemistry-Paraffin: AG-2/AGR2 Antibody - BSA Free [NB110-17780]

Immunohistochemistry-Paraffin: AG-2/AGR2 Antibody - BSA Free [NB110-17780]

Immunohistochemistry-Paraffin: AG-2 Antibody [NB110-17780] - Immunohistochemical staining with NB110-17780, anti- AG-2 antibody, in formalin-fixed, paraffin-embedded normal colon tissue at 1:100 dilution.
AG-2/AGR2 Antibody - BSA Free

Immunohistochemistry: AG-2/AGR2 Antibody - BSA Free [NB110-17780] -

Immunohistochemistry: AG-2/AGR2 Antibody - BSA Free [NB110-17780] - SATB1 immunohistochemistry staining. A, benign prostate hyperplasia. B, prostatic carcinoma with metastasis. C, prostatic carcinoma without metastasis. D, negative control. Magnification: 400 × . Image collected & cropped by CiteAb from the following publication (https://pubmed.ncbi.nlm.nih.gov/23642278), licensed under a CC-BY license. Not internally tested by Novus Biologicals.
AG-2/AGR2 Antibody - BSA Free

Immunohistochemistry: AG-2/AGR2 Antibody - BSA Free [NB110-17780] -

Immunohistochemistry: AG-2/AGR2 Antibody - BSA Free [NB110-17780] - SATB1 immunohistochemistry staining. A, benign prostate hyperplasia. B, prostatic carcinoma with metastasis. C, prostatic carcinoma without metastasis. D, negative control. Magnification: 400 × . Image collected & cropped by CiteAb from the following publication (https://pubmed.ncbi.nlm.nih.gov/23642278), licensed under a CC-BY license. Not internally tested by Novus Biologicals.
AG-2/AGR2 Antibody - BSA Free

Immunohistochemistry: AG-2/AGR2 Antibody - BSA Free [NB110-17780] -

Immunohistochemistry: AG-2/AGR2 Antibody - BSA Free [NB110-17780] - SATB1 immunohistochemistry staining. A, benign prostate hyperplasia. B, prostatic carcinoma with metastasis. C, prostatic carcinoma without metastasis. D, negative control. Magnification: 400 × . Image collected & cropped by CiteAb from the following publication (https://pubmed.ncbi.nlm.nih.gov/23642278), licensed under a CC-BY license. Not internally tested by Novus Biologicals.
AG-2/AGR2 Antibody - BSA Free

Immunohistochemistry: AG-2/AGR2 Antibody - BSA Free [NB110-17780] -

Immunohistochemistry: AG-2/AGR2 Antibody - BSA Free [NB110-17780] - SATB1 immunohistochemistry staining. A, benign prostate hyperplasia. B, prostatic carcinoma with metastasis. C, prostatic carcinoma without metastasis. D, negative control. Magnification: 400 × . Image collected & cropped by CiteAb from the following publication (https://pubmed.ncbi.nlm.nih.gov/23642278), licensed under a CC-BY license. Not internally tested by Novus Biologicals.

Applications for AG-2/AGR2 Antibody - BSA Free

Application
Recommended Usage

Immunohistochemistry

1:100

Immunohistochemistry-Paraffin

1:100

Western Blot

reported in scientific literature (PMID 22072305)

Formulation, Preparation, and Storage

Purification

Immunogen affinity purified

Formulation

PBS and 30% Glycerol

Format

BSA Free

Preservative

0.05% Sodium Azide

Concentration

1.0 mg/ml

Shipping

The product is shipped with polar packs. Upon receipt, store it immediately at the temperature recommended below.

Stability & Storage

Store at 4C short term. Aliquot and store at -20C long term. Avoid freeze-thaw cycles.

Background: AG-2/AGR2

Originally discovered in Xenopus laevis wherein it plays a role during early neural development, AGR2 (anterior gradient protein 2 homolog) is now known as a member of protein disulfide isomerase (PDI) family of ER-resident proteins which is expressed in a variety of normal as well as transformed epithelial tissues. AGR2 has been implicated in the folding of proteins as a chaperone protein. It interacts with LYPD3, DAG1 (alphaDAG1) and MUC2 (disulfide-linked), and is essential for MUC2 translation as well as secretion. AGR2 plays a key role in the production of mucus by intestinal cells and has also been suggested to be a proto-oncogene that may involve in cellular migration, differentiation and growth. Differential expression of AGR2 was first found in estrogen receptor (ER)-positive breast cancer cell lines and subsequently, elevated AGR2 levels have been seen in subsets of other cancers also wherein its upregulation enhances classical hallmarks of cancer such as metastasis, invasion, colony formation, and proliferation.

Long Name

Anterior Gradient 2 Homolog

Alternate Names

AG2, AGR2, GOB-4, HPC8, PDIA17

Entrez Gene IDs

10551 (Human)

Gene Symbol

AGR2

UniProt

O95994 (Human)

Additional AG-2/AGR2 Products

Product Documents for AG-2/AGR2 Antibody - BSA Free

Certificate of Analysis

To download a Certificate of Analysis, please enter a lot or batch number in the search box below.

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Product Specific Notices for AG-2/AGR2 Antibody - BSA Free

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

Related Research Areas

Cancer Biomarkers

Citations for AG-2/AGR2 Antibody - BSA Free

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Protocols

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