Chemical Name: cis-2-[[1-(4-Chlorophenyl)-1H-tetrazol-5-yl]thio]-1-(1,2,3,4,4a,9b-hexahydro-2,8-dimethyl-5H-pyrido[4,3-b]indol-5-yl)-ethanone
Biological ActivityAG 205 is a progesterone receptor membrane component 1 (Pgrmc1) ligand. Inhibits cell cycle progression and cell viability in cancer cell lines. Inhibits progesterone induced cytosolic Ca2+ increases in GnRH neurons in vitro.
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Tocris products are intended for laboratory research use only, unless stated otherwise.
Progesterone receptor membrane component 1 (Pgrmc1): a heme-1 domain protein that promotes tumorigenesis and is inhibited by a small molecule.
Ahmed et al.
Progesterone directly and rapidly inhibits GnRH neuronal activity via progesterone receptor membrane component 1.
Bashour and Wray
A structure-based strategy for discovery of small ligands binding to functionally unknown proteins: combination of in silico screening and surface plasmon resonance measurements.
Yoshitani et al.
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