Selective ErbB2 inhibitor (IC50
values are 0.15 and 19 μ
M at ErbB2 and ErbB1 respectively). Preferentially triggers p38 MAP kinase-dependent apoptosis in androgen-independent prostate cancer cells.
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
Tyrphostins. 3. Structure-activity relationship studies of α-substituted benzylidenemalononitrile 5-S-aryltyrphostins.
Gazit et al.
Tyrphostin AG825 triggers p38 mitogen-activated protein kinase-dependent apoptosis in androgen-independent prostate cancer cells C4 and C4-21.
Murillo et al.
Cancer Res., 2001;61:7408
Selective inhibition of the epidermal growth factor and HER2/Neu receptors by tyrphostins.
Osherov et al.
The citations listed below are publications that use Tocris products. Selected citations for AG 825 include:
Showing Results 1 - 4 of 4